Comparison of Tidal Volume Between Pediatric Anaesthesia and Paediatric Intensive Care Patients

Overview

Paediatric anaesthesiology and paediatric intensive care unit data will be retrospectively screened for the data regarding mechanical ventilation. The primary aim will be the tidal volume setting and the secondary the level of positive end-expiration pressure (PEEP) according to the inspired oxygen fraction (FIO2), and the level of driving pressure.

Full Title of Study: “Comparison of Tidal Volume Between Pediatric Anaesthesia and Paediatric Intensive Care Patients: Retrospective Study”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: December 31, 2022

Detailed Description

Protective positive pressure ventilation (tidal volume ≤6 mL/kg) in adult patients in intensive care is currently considered as a standard procedure. It is associated with a reduction of morbidity and positive outcome. In paediatric patients there are available only limited information related to the size of the tidal volume and it is recommended to use the volume between 5 and 8 mL per kg for the whole spectrum of ages of pediatric patients. The aim of this retrospective observational study is to evaluate the tidal volumes used in clinical practice in pediatric patients during general anesthesia and compared it to the tidal volumes used in paediatric critical care. Data will be harvested from the anaesthesiology records and from the paediatric intensive care unit charts. The tidal volume will calculated per kg of actual weight.

Interventions

  • Other: Data from anaesthesia records for ventilation setting screening
    • Data from anaesthesia records will be retrospectively screened for the ventilation settings
  • Other: Data from intensive care records for ventilation setting screening
    • Data from paediatric intensive care charts will be retrospectively screened for the ventilation settings

Arms, Groups and Cohorts

  • Paediatric patients anaesthesia
    • Paediatric patients who underwent diagnostic or surgical procedure under general anaesthesia with the need for mechanical ventilation in the selected time period.
  • Paediatric patients intensive care
    • Paediatric patients admitted to the paediatric intensive care unit with the need for mechanical ventilation in the selected time period

Clinical Trial Outcome Measures

Primary Measures

  • Tidal volume
    • Time Frame: Intraoperative period
    • Tidal volume will be evaluated in the paediatric patients in anaesthesia and in intensive care unit

Secondary Measures

  • Positive end-expiratory pressure settings according to the inspiration fraction of oxygen
    • Time Frame: Intraoperative period
    • Positive end-expiratory pressure will be evaluated in the paediatric patients in anaesthesia and in intensive care unit
  • Driving pressure
    • Time Frame: Intraoperative period
    • Driving pressure will be calculated from peak pressure minus PEEP in patients on mechanical ventilation in anaesthesia and in intensive care unit

Participating in This Clinical Trial

Inclusion Criteria

  • Paediatric patients on mechanical ventilation in anaesthesia department – Paediatric patients on mechanical ventilation in intensive care department – In selected study period between 1.1.2018 – 31.1.2019 Exclusion Criteria:

  • Age outside selected limits – Insufficient data

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: 19 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Brno University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Petr Štourač, MD, assoc.prof.MD,Ph.D – Brno University Hospital
  • Overall Official(s)
    • Petr Stourac, assoc.Prof.MD.Ph.D, Study Chair, University Hospital Brno
  • Overall Contact(s)
    • Petr Stourac, assoc.Prof.MD.Ph.D, 532234404, stourac.petr@fnbrno.cz

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