Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia in Multiple Sclerosis Patients

Overview

Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Moderate intensity strength training has been shown to improve strength and mobility in persons with MS. It was suggested that whole-body vibration training (WBVT) is effective to improve muscle strength, such as resistance training, resulting from both neural and structural adaptations. On the other hand, traditional strength training in hypoxia has garnered much attention. This method has shown improvements in isometric strength and increases in muscle size.

Full Title of Study: “Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia Condition on Neuromuscular Performance and Mobility in Patients With Multiple Sclerosis”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Supportive Care
    • Masking: Single (Participant)
  • Study Primary Completion Date: July 30, 2018

Detailed Description

– Crossover. – 13 patients with multiple sclerosis were recruited. – Patients performed two sessions: whole-body vibration training in normoxia condition and whole-body vibration in hypoxia condition.

Interventions

  • Other: Exercise
    • Whole-body vibration training in hypoxia and normoxia condition

Arms, Groups and Cohorts

  • Experimental: Whole-body vibration in normoxia condition
    • Training session in normoxia condition
  • Experimental: Whole-body vibration in hypoxia condition
    • Training session in hypoxia condition

Clinical Trial Outcome Measures

Primary Measures

  • Maximal Voluntary Isometric Contraction of Knee Extension
    • Time Frame: Immediately before the training sessions
  • Maximal Voluntary Isometric Contraction of Knee Extension
    • Time Frame: Immediately after the training sessions
  • Rate of Force Development
    • Time Frame: Immediately before the training sessions
  • Rate of Force Development
    • Time Frame: Immediately after the training sessions
  • Central Activation Ratio
    • Time Frame: Immediately before the training sessions
  • Central Activation Ratio
    • Time Frame: Immediately after the training sessions
  • Biomechanical study of the walk by video recording
    • Time Frame: Immediately before the training sessions
    • Kinematic analysis of knee and ankle angles during walking
  • Biomechanical study of the walk by video recording
    • Time Frame: Immediately after the training sessions
    • Kinematic analysis of knee and ankle angles during walking
  • Biomechanical study of the walk by video recording
    • Time Frame: Immediately before the training sessions
    • Stride amplitude during walking
  • Biomechanical study of the walk by video recording
    • Time Frame: Immediately after the training sessions
    • Stride amplitude during walking
  • Spasticity
    • Time Frame: Immediately before the training sessions
    • Pendulum test
  • Spasticity
    • Time Frame: Immediately after the training sessions
    • Pendulum test

Secondary Measures

  • Rate of Perceived Exertion
    • Time Frame: Immediately before the training sessions
    • RPE Scale 6-20
  • Rate of Perceived Exertion
    • Time Frame: Immediately after the training sessions
    • RPE Scale 6-20
  • Walking speed
    • Time Frame: Immediately before the training sessions
    • Test 10 m-walks
  • Walking speed
    • Time Frame: Immediately after the training sessions
    • Test 10 m-walks
  • Static balance
    • Time Frame: Immediately before the training sessions
    • Romberg Test with eyes open and closed. Analysis with force plates
  • Static balance
    • Time Frame: Immediately after the training sessions
    • Romberg Test with eyes open and closed. Analysis with force plates
  • Muscle oxygenation in soleus
    • Time Frame: Immediately before the training sessions
    • MOXY’s
  • Muscle oxygenation in soleus
    • Time Frame: Immediately after the training sessions
    • MOXY’s

Participating in This Clinical Trial

Inclusion Criteria

  • mild or moderate disability with clinical mild spastic-ataxic gait disorder. – stable phase of the disease. Exclusion Criteria:

  • Expanded Disability Status Scale (EDSS) < 6. – relapsing disease within the preceding 12 months. – corticosteroid treatment within the last months before study inclusion.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Universidad Católica San Antonio de Murcia
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jacobo Á. Rubio, Profesor Titular – Universidad Católica San Antonio de Murcia

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