Evaluation of the Use of Cefoxitin in Combination in Continuous Parenteral Administration in the Treatment of Bone and Joint Infections
Overview
Cephamycin related to 2nd generation cephalosporins, the use of cefoxitin has long been limited to antibiotic prophylaxis. Because of its spectrum (sensitive staphylococci, enterobacteria including ESBL, streptococci, anaerobes), its stability and its low cost, it could be useful in curative bone and joint infections, especially in case of infection polymicrobial disease in patients for whom antibiotic alternative per os is limited.
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Retrospective
- Study Primary Completion Date: March 1, 2018
Interventions
- Other: bone and joint infection treated with cefoxitin
- the patients had cefoxitin in combination in continuous parenteral administration to treat their bone / joint infection
Arms, Groups and Cohorts
- bone and joint infection treated with cefoxitin
- patients having had a bone or joint infection treated by cefoxitin in combination. Cefoxitin has been administered by continuous way, at home. A serum dosage of cefoxitin has been systematically achieved at equilibrium.
Clinical Trial Outcome Measures
Primary Measures
- Rate of Treatment Failure
- Time Frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
- Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin
Secondary Measures
- Rate of use of this strategy
- Time Frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
- Descriptions of patients managed with this strategy
Participating in This Clinical Trial
Inclusion Criteria
- patients havind had a bon and joint infeciton treated with cefoxitin in combination in continuous parenteral administration Exclusion Criteria:
-
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 100 Years
Investigator Details
- Lead Sponsor
- Hospices Civils de Lyon
- Provider of Information About this Clinical Study
- Principal Investigator: Eugénie MABRUT, clinical research assistant – Hospices Civils de Lyon
- Overall Official(s)
- Tristan Ferry, Md,PhD, Principal Investigator, Hospices Civils de Lyon
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