Human Beta-defensin 1 in Vitiligo

Overview

There is a need to know the role of human beta defensin-1 in vitiligo pathogenesis and the probability of finding newer and effective therapy for vitiligo in the future.

Full Title of Study: “Estimation of Tissue Level of Human Beta-defensin 1 (HBD-1) in Vitiligo Before and After Narrowband UVB Phototherapy: a Case-control Study”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: December 2019

Interventions

  • Other: skin biopsy before and after NB-UVB phototherapy
    • skin biopsy before and after NB-UVB phototherapy to measure tissue human beta-defensin 1

Arms, Groups and Cohorts

  • Experimental: vitiligo patients
    • Tissue levels of human beta-defensin 1 in vitiligo patients before and after NB-UVB phototherapy
  • Active Comparator: Healthy controls
    • Tissue levels of human beta-defensin 1 in healthy controls

Clinical Trial Outcome Measures

Primary Measures

  • Tissue levels of human beta-defensin 1 before and after NB-UVB phototherapy
    • Time Frame: 6 months to 1 year

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with non-segmental vitiligo.
  • Both genders.
  • Age more than 18 years old.
  • New cases or cases not receiving any treatment for at least 3 months prior to the study.

Exclusion Criteria

  • Universal or segmental vitiligo.
  • Any contraindication to phototherapy treatment.
  • History of autoimmune diseases or other systemic diseases.
  • Any other skin disease.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Cairo University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Maha Fathy Elmasry, principal investigator – Cairo University

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