Sarcopenia And Balance In Postmenopausal Osteoporosis

Overview

The study was performed on 53 postmenopausal osteoporosis patients who presented to our osteoporosis outpatient clinic. Following written informed consent, patients were evaluated for sarcopenia according to the sarcopenia algorithm proposed by the European Working Group on Sarcopenia in Older People (EWGSOP). Algorithm parameters were walking speed, muscle strength and muscle mass measurements. We used Timed Up and Go Test (TUG) for evaluation of walking speed, Jamar Hand Dynamometer for muscle strength assessment, and calf circumference for muscle mass measurement. Balances of the patients were evaluated with Berg Balance Scale (BBS) and functional skills were evaluated with the Timed Up and Go Test (TUG). Other clinical parameters (age, body mass index (BMI), 25OHvitD level, menopause age, fall within the last year, fracture history, history of fracture in mother) were questioned.

Study Type

  • Study Type: Interventional
  • Study Design
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: March 31, 2019

Detailed Description

The study was performed on 53 postmenopausal osteoporosis patients who presented to our osteoporosis outpatient clinic. Following written informed consent, patients were evaluated for sarcopenia according to the sarcopenia algorithm proposed by the European Working Group on Sarcopenia in Older People (EWGSOP). Algorithm parameters were walking speed, muscle strength and muscle mass measurements. We used Timed Up and Go Test (TUG) for evaluation of walking speed, Jamar Hand Dynamometer for muscle strength assessment, and calf circumference for muscle mass measurement. Balances of the patients were evaluated with Berg Balance Scale (BBS) and functional skills were evaluated with the Timed Up and Go Test (TUG). Other clinical parameters (age, body mass index (BMI), 25OHvitD level, menopause age, fall within the last year, fracture history, history of fracture in mother) were questioned. SPSS 22.0 program will be used for statistical evaluation and correlation analysis will be done.

Interventions

  • Diagnostic Test: Berg Balance Scale
    • Berg Balance Scale performed for balance disorder
  • Diagnostic Test: Timed Up and Go Test
    • Timed Up and Go Test for walking speed
  • Diagnostic Test: Jamar hand dynamometer
    • Jamar hand dynamometer for grip strength which correlates with muscle strength of patient
  • Diagnostic Test: Calf circumference
    • Calf circumference for muscle mass evaluation. Calf circumference is an anthropometric measurement which correlates with muscle mass.

Arms, Groups and Cohorts

  • Experimental: postmenopausal osteoporosis
    • Postmenopausal osteoporotic patients evaluated for sarcopenia and balance disorders

Clinical Trial Outcome Measures

Primary Measures

  • sarcopenia in postmenopausal osteoporotic patients
    • Time Frame: 6 months
    • sarcopenia evaluated according to EWGSOP algorithm which includes walking speed, muscle strength and muscle mass measures
  • balance disorder in postmenopausal osteoporotic patients
    • Time Frame: 6 months
    • balance evaluated by Berg Balance Scale ( 0-56 scored scale , bigger score indicates better balance, scores under 41 indicates bigger risk of falling )

Participating in This Clinical Trial

Inclusion Criteria

  • Having postmenopausal osteoporosis
  • No other disease that can cause balance disorder
  • Volunteer participation in the study

Exclusion Criteria

  • To have a disease that will cause balance disorder,
  • Having understanding problem to prevent communication with the patient,
  • The lack of motor function to the balance device.

Gender Eligibility: Female

Postmenopausal osteoporotic patients

Minimum Age: 50 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Istanbul Medeniyet University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Bilinç Doğruöz Karatekin, MD, Research Assistant of PMR – Istanbul Medeniyet University

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