Cystic Fibrosis and Cognitive Function

Overview

The long-term goal of this project is to examine the effects of cystic fibrosis (CF) and cystic fibrosis related diabetes (CFRD) on brain structure and function

Full Title of Study: “Effects of Cystic Fibrosis and Cystic Fibrosis Related Diabetes on Brain Structure and Cognitive Function”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 10, 2019

Detailed Description

A growing body of evidence suggests that hyperglycemia in type 1 and type 2 diabetes is associated with alterations in brain structure and cognitive impairment. People with cystic fibrosis related diabetes (CRFD) are exposed to hyperglycemia as seen in other forms of diabetes, and cystic fibrosis is also associated with chronic systemic inflammation. Both hyperglycemia and chronic inflammation have been postulated to affect brain structure and function. Cystic fibrosis trans-membrane conductance regulator (CFTR). protein is widely expressed in the neurons of the brain including in the hippocampus The hippocampus plays an essential role in learning and memory processing and is thought to be particularly vulnerable to effects of metabolic stressors. The expression of CFTR in neurons has several potential implications for central nervous system function, including cognition. The long-term goal of this project is to examine the effects of cystic fibrosis (CF) and cystic fibrosis related diabetes (CFRD) on brain structure and function.

Arms, Groups and Cohorts

  • Cystic Fibrosis
    • Subjects with cystic fibrosis
  • controls
    • matched healthy controls

Clinical Trial Outcome Measures

Primary Measures

  • MRI outcome
    • Time Frame: baseline
    • Measure the differences in the microstructure (fractional anisotropy) of hippocampus, comparing subjects with cystic fibrosis and healthy controls

Secondary Measures

  • Cognitive function
    • Time Frame: baseline
    • Compare performance on neurocognitive function testing in subjects with cystic fibrosis and healthy controls. Multiple cognitive domains will be examined including intellectual function, processing speed. attention and memory.

Participating in This Clinical Trial

Inclusion Criteria

patients with Cystic fibrosis Exclusion Criteria:

  • History of stroke – History of epilepsy – History of neurosurgical procedures – Past or current history of severe psychiatric illness – Pass or current history of alcohol or substance abuse – Presence of metallic substances in body or inability to remove before imaging procedure – History of claustrophobia or known inability to tolerate MRI – Current pregnancy – Inability to consent

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Minnesota
  • Provider of Information About this Clinical Study
    • Sponsor

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