Effectiveness of High Intensity Interval Training (HIIT) on Improving Cardiometabolic Health After SCI

Overview

Testing the efficacy of high intensity interval training (HIIT), as compared to current research supporting moderate intensity continuous training (MICT), as a means to improve cardiometabolic health after spinal cord injury.

Full Title of Study: “High-intensity Interval Training Versus Moderate Intensity Continuous Training as a Means to Improve Cardiometabolic Health After Spinal Cord Injury”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Prevention
    • Masking: None (Open Label)
  • Study Primary Completion Date: May 30, 2019

Detailed Description

This study aims to challenge the effectiveness of the current aerobic exercise recommendations for individuals with spinal cord injuries (SCI). Currently, moderate intensity continuous training (MICT) is suggested however this study intends to explore the effectiveness of high intensity interval training (HIIT). To do so, approximately 8 individuals with SCI will be undergo a 6 week HIIT intervention consisting of 3 sessions per week. With a focus on cardiometabolic health markers (listed in outcome measure section), we aim to provide support for HIIT as a viable method of mitigating cardiovascular risk in a SCI population.

Interventions

  • Other: High Intensity Interval Training
    • Participants assigned to this group will perform a very mild 5-minute warm-up (0 resistance, and 60 rpm), followed by 5 one-minute bouts of high intensity exercise, with 90 seconds between each bout. These bouts will be followed by a 3-minute cool down (0 resistance, and 60 rpm). The high-intensity exercise will be performed at an intensity of 17 on the Borg rating of perceived exertion (RPE) scale (very hard), and the 90 second active rest intervals will be performed at an intensity of 7-9 (very, very light – very light). The exercise will be performed on the NuStep machine 3 times a week for 6 weeks.

Arms, Groups and Cohorts

  • Experimental: High Intensity Interval Training Group
    • Approximately eight individuals with spinal cord injuries will participate in high intensity interval training for 6 weeks

Clinical Trial Outcome Measures

Primary Measures

  • Waist circumference (inches)
    • Time Frame: 6 weeks
    • Central adiposity will be measured by tape measure to monitor possible weight loss
  • Cholesterol
    • Time Frame: 6 weeks
    • Total and HDL cholesterol will be measured in serum
  • Triglycerides
    • Time Frame: 6 weeks
    • Triglycerides will be measured in serum
  • Glycated Hemoglobin (HbA1c)
    • Time Frame: 6 weeks
    • Glycated hemoglobin will be measured in whole blood as an indicator of diabetic risk
  • Tumor necrosis factor (TNF-a)
    • Time Frame: 6 weeks
    • TNF-a will be used as an inflammatory representative and will be measured in serum
  • Interleukin – 10 (IL-10)
    • Time Frame: 6 weeks
    • IL-10 will will be used as an anti-inflammatory representative and will be measured in serum
  • Pulse Wave Velocity
    • Time Frame: 6 weeks
    • Arterial stiffness, a common measure for cardiac risk will be measured
  • Blood pressure
    • Time Frame: 6 weeks
    • Measured through a digital cuff, the focus will be on both systolic and diastolic
  • Peak Oxygen Consumption (VO2 peak)
    • Time Frame: 6 weeks
    • VO2 peak will be measured by a Moxus metabolic cart to determine changes in fitness
  • C Reactive Protein (CRP)
    • Time Frame: 6 weeks
    • CRP will will be used as an inflammatory representative and will be measured in serum
  • Leptin
    • Time Frame: 6 weeks
    • Leptin will will be used as a body fat representative and will be measured in serum
  • Adiponectin
    • Time Frame: 6 weeks
    • Adiponectin will will be used as a surrogate for insulin resistance and will be measured in serum

Secondary Measures

  • Physical Activity Enjoyment Scale (PACES)
    • Time Frame: 6 weeks
    • All participants will complete the physical activity enjoyment scale (PACES) to indicate enjoyment of HIIT. With a total of 18 questions, options 1 through 7 going from a positive to a negative overall experience with the HIIT protocol will be documented.

Participating in This Clinical Trial

Inclusion Criteria

  • Individuals with a spinal cord injury (paraplegia or tetraplegia, complete or incomplete) who are at least one-year post injury. – Declared medically stable, and able to communicate clearly in English.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Brock University
  • Provider of Information About this Clinical Study
    • Principal Investigator: David Ditor, David Ditor, PhD – Professor, Kinesiology – Brock University
  • Overall Official(s)
    • Mitchel Gibson, BKin, Principal Investigator, Masters Student
    • Aaron Donst, BKin, Principal Investigator, Masters Student

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.