Vitamin D has many biological functions. Vitamin D receptors are widely distributed in the male and female reproductive system. Animal experiments have shown that vitamin D deficiency can affect hormone synthesis and gamete formation, reduce sperm motility, and may be related to diseases such as PCOS and endometriosis. Population studies suggest that vitamin D may be related to androgen levels and sperm quality, but whether vitamin D affects the outcome of assisted reproduction is controversial and inconclusive. This study intends to explore whether vitamin D affects the outcome of assisted reproduction through a large sample cohort study.
Full Title of Study: “Effect of Vitamin D on Outcome of Assisted Reproductive Technology(ART)”
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: December 1, 2019
Vitamin D plays an important role in reproduction, while there is high prevalence of vitamin D deficiency. Serum 25(OH)D was categorized according to clinically accepted ranges for vitamin D deﬁciency (<20 ng/mL), insufﬁciency (20-30 ng/mL), and replete (>30 ng/mL).
This is a retrospective cohort study of about 2000 infertile couples who undergo their ﬁrst IVF/ICSI and IUI cycle at Reproductive Medicine Center of Peking University Third Hospital. Patients will be excluded if they refuse to be recruited. Serum samples are collected the day when patients first time to Reproductive Medicine Center and were stored at -20℃ until assayed. Life style of patients is collected by questionair. Vitamin D status is measured by assessing circulating levels of 25(OH)D in frozen, never previously thawed serum samples using radioimmunoassay.
The investigators will comapere the ART outcomes in different groups according to serum 25(OH)D status.
In female, the primary outcome is clinical pregnancy rates deﬁned as the presence of an intrauterinesac with an embryonic pole demonstrating cardiacactivity at 7 weeks of gestation. Secondary outcomes are quality of embryo, positive hCG rates and live birth rates.
In male, the primary outcome is semen quality, such as semen volume, sperm concentration, sperm motility, morphologically normal percent and progressive motile spermatozoa percent. Secondary outcomes are clinical pregnancy rates and live birth rates.
Arms, Groups and Cohorts
- vitamin D-ART
- Infertile couples who undergo their ﬁrst IVF/ICSI and IUI cycle in Reproductive Medicin Center of Peking university Third Hosiptal.
Clinical Trial Outcome Measures
- clinical pregnancy rates
- Time Frame: 12 weeks after transplantation
- Time Frame: the presence of an intrauterinesac with an embryonic pole demonstrating cardiacactivity
Participating in This Clinical Trial
infertile couples who undergo their ﬁrst IVF/ICSI and IUI cycle at Reproductive Medicine Center of Peking University Third Hospital.
refusing to be recruited.
Gender Eligibility: All
Minimum Age: N/A
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
- Lead Sponsor
- Peking University Third Hospital
- Provider of Information About this Clinical Study
- Principal Investigator: Zhi Xu, associate professor – Peking University Third Hospital
- Overall Official(s)
- XU ZHI, Study Chair, Peking University Third Hospital
- Overall Contact(s)
- XU ZHI, doctor, 01082266757, firstname.lastname@example.org
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