This study involves the collection ocular lens tissue from individuals with Down syndrome and age-matched controls at the time of cataract surgery.
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: May 2020
Individuals with Down syndrome have an increased rate of cataract. The reason for this increase is unclear. Normally, once cataracts become a significant impairment, an ophthalmologist will determine when cataract surgery should be performed. When this surgery is performed, cataractous tissues are cut out and discarded with medical waste. In this study, these tissue will be collected and protein analysis performed to determine what changes in different proteins are found in Down syndrome lenses as compared to normal cataractous lenses.
- Procedure: cataract surgery
- tissue collection.
Arms, Groups and Cohorts
- Down syndrome
- Individuals with Down syndrome undergoing cataract surgery.
- Age-matched controls undergoing cataract surgery.
Clinical Trial Outcome Measures
- Change in protein composition
- Time Frame: one week after collection of tissue
- western blot analysis of proteins from cataractous tissue
Participating in This Clinical Trial
- Undergoing cataract surgery for lens extraction.
- Known genetic cause other than Down syndrome causing cataract.
Gender Eligibility: All
Minimum Age: 1 Month
Maximum Age: 18 Years
Are Healthy Volunteers Accepted: No
- Lead Sponsor
- University of Colorado, Denver
- Children’s Hospital Colorado
- Provider of Information About this Clinical Study
- Overall Contact(s)
- Niklaus H Mueller, 3037249995, firstname.lastname@example.org
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