Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome


This study involves the collection ocular lens tissue from individuals with Down syndrome and age-matched controls at the time of cataract surgery.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: May 2020

Detailed Description

Individuals with Down syndrome have an increased rate of cataract. The reason for this increase is unclear. Normally, once cataracts become a significant impairment, an ophthalmologist will determine when cataract surgery should be performed. When this surgery is performed, cataractous tissues are cut out and discarded with medical waste. In this study, these tissue will be collected and protein analysis performed to determine what changes in different proteins are found in Down syndrome lenses as compared to normal cataractous lenses.


  • Procedure: cataract surgery
    • tissue collection.

Arms, Groups and Cohorts

  • Down syndrome
    • Individuals with Down syndrome undergoing cataract surgery.
  • Control
    • Age-matched controls undergoing cataract surgery.

Clinical Trial Outcome Measures

Primary Measures

  • Change in protein composition
    • Time Frame: one week after collection of tissue
    • western blot analysis of proteins from cataractous tissue

Participating in This Clinical Trial

Inclusion Criteria

  • Undergoing cataract surgery for lens extraction.

Exclusion Criteria

  • Known genetic cause other than Down syndrome causing cataract.

Gender Eligibility: All

Minimum Age: 1 Month

Maximum Age: 18 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Colorado, Denver
  • Collaborator
    • Children’s Hospital Colorado
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Contact(s)
    • Niklaus H Mueller, 3037249995, niklaus.mueller@ucdenver.edu

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.