Effect of Some Drugs on Liver Fibrosis

Overview

Effect of Some Drugs on Liver Fibrosis

Full Title of Study: “Clinical Study Evaluating the Efficacy of Renin Angiotensin System Inhibitors on the Extent of Liver Fibrosis in Patients With Chronic Hepatitis C”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: October 2026

Detailed Description

The study aimed at evaluating the effect of Some Drugs on Liver Fibrosis

Interventions

  • Drug: Candesartan
    • Candesartan 8 mg/day
  • Drug: Ramipril
    • ramipril 1.25 mg/day

Arms, Groups and Cohorts

  • No Intervention: Control group
    • No intervention
  • Active Comparator: Candesartan
    • Candesartan 8 mg/day
  • Active Comparator: Ramipril
    • Ramipril 1.25 mg/day

Clinical Trial Outcome Measures

Primary Measures

  • Change in Fibroscan or APRI score
    • Time Frame: 6 months
    • Change in Fibroscan or APRI score

Participating in This Clinical Trial

Inclusion Criteria

  • chronic hepatitis C Exclusion Criteria:

  • Acute hepatitis – Thalassemia

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Sherief Abd-Elsalam
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Sherief Abd-Elsalam, Ass. Prof. Tropical Medicine – Tanta University
  • Overall Official(s)
    • Gamal El-azab, Prof, Principal Investigator, Clinical pharmacy Department- Tanta University
    • Tarek Mostafa, Prof, Study Director, Cardiology Department- Tanta University
    • Gamal Badra, Prof, Study Chair, National Hepatology Institute – Egypt
    • Abeer El-Motwally, Msc, Study Chair, Clinical pharmacy Department-Tanta University
  • Overall Contact(s)
    • Sherief Abd-Elsalam, Ph D, 00201147773440, sheriefabdelsalam@yahoo.com

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