The Effect of GIP(3-30)NH2
Overview
Infusion of glucose-dependent insulintropic polypeptide (GIP) receptor antagonist and evaluation of effect of insulin secretion in healthy subjects.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Basic Science
- Masking: Double (Participant, Investigator)
- Study Primary Completion Date: March 1, 2019
Detailed Description
Infusion of glucose-dependent insulintropic polypeptide (GIP) receptor antagonist and evaluation of effect of insulin secretion in healthy subjects. Six study hyperglycemic clamps (10 mmol/l) pr. participant.
Interventions
- Other: GIP receptor antagonist
- GIP receptor antagonist
- Other: GIP receptor agonist
- GIP(1-42)
- Other: Saline
- Placebo (vehicle for infusions)
Arms, Groups and Cohorts
- Placebo Comparator: Placebo+placebo
- Saline infusions
- Active Comparator: GIP+placebo
- GIP(1-42), receptor agonist
- Experimental: GIP+dose 1
- GIP(1-42) and lowest dose of GIP(3-30)NH2
- Experimental: GIP+dose 2
- GIP(1-42) and dose of GIP(3-30)NH2
- Experimental: GIP+dose 3
- GIP(1-42) and dose of GIP(3-30)NH2
- Experimental: GIP+dose4
- GIP(1-42) and highest dose of GIP(3-30)NH2
Clinical Trial Outcome Measures
Primary Measures
- Insulin secretion
- Time Frame: 8 weeks
- Insulin secretion rates (ISR) calculated from serum levels of C-peptide
Participating in This Clinical Trial
Inclusion Criteria
- Healthy – BMI 19-28 kg/m*m – Stable body weight Exclusion Criteria:
- Diabetes – Anemia – First-degree relatives with diabetes
Gender Eligibility: Male
Minimum Age: 18 Years
Maximum Age: 70 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- University Hospital, Gentofte, Copenhagen
- Collaborator
- Steno Diabetes Center Copenhagen
- Provider of Information About this Clinical Study
- Principal Investigator: Lærke Smidt Gasbjerg, MD – University Hospital, Gentofte, Copenhagen
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