Trends of Mastectomy and Breast-Conserving Surgery in Female Breast Cancer Patients

Overview

Breast cancer is the most common cancer in women across the world, accounting for 25.2% of cancer cases among females and 14.7% of cancer-related deaths among females worldwide. The survival rates are markedly lower in the developing countries compared to developed countries, as well as the age at diagnosis. Core management of breast cancer includes surgical removal of the tumor either by breast-conserving surgery (BCS) or mastectomy (removal of the whole breast). Choosing between these two procedures may be influenced by factors that have yet to be studied in Saudi Arabia. The investigators aimed to determine the prevalence of BCS and mastectomy and the factors that may influence the choice of procedure. This retrospective study was carried out by reviewing the records of female breast cancer patients who underwent BCS or mastectomy at King Abdulaziz University Hospital between 2009 to June 2017, excluding those with metastasis (distant spread of the cancer) or recurrence. Using frequencies for the rate, and multivariate tests, the investigators analyzed different demographic, clinicopathological, and radiological factors to detect correlations with procedure choice.

Full Title of Study: “Trends of Mastectomy and Breast-Conserving Surgery and Related Factors in Female Breast Cancer Patients Treated at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, 2009-2017”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: August 2, 2018

Interventions

  • Procedure: Mastectomy
    • Removal of the whole breast
  • Procedure: Breast-Conserving Surgery
    • Removal of the cancerous tissue only

Arms, Groups and Cohorts

  • Mastectomy
  • Breast-Conserving Surgery

Clinical Trial Outcome Measures

Primary Measures

  • Prevalence of each of mastectomy and breast-conserving surgery
    • Time Frame: 2009-2017
    • The percentage of of patients who underwent each surgery

Secondary Measures

  • The relationship between the choice of procedure and the patients’ age (in years)
    • Time Frame: 2009-2017
    • Statistical analysis using independent sample T-test and binary logistic regression
  • The relationship between the choice of procedure and the use of preoperative chemotherapy (also called “neoadjuvant chemotherapy”)
    • Time Frame: 2009-2017
    • Statistical analysis using Chi-square test and binary logistic regression
  • The relationship between the choice of procedure and the tumor’s laterality (right versus left breast cancer)
    • Time Frame: 2009-2017
    • Statistical analysis using Chi-square test and binary logistic regression
  • The relationship between the choice of procedure and the tumor’s focality (whether it is composed of more than one mass)
    • Time Frame: 2009-2017
    • Statistical analysis using Chi-square test and binary logistic regression
  • The relationship between the choice of procedure and the tumor’s centricity (whether it involves more than one quadrant of the breast)
    • Time Frame: 2009-2017
    • Statistical analysis using Chi-square test and binary logistic regression
  • The relationship between the choice of procedure and the tumor’s size (in centimeters)
    • Time Frame: 2009-2017
    • Statistical analysis using independent sample T-test and binary logistic regression
  • The relationship between the choice of procedure and the tumor’s stage (using the 7th “American Joint Committee on Cancer”‘s staging guidelines)
    • Time Frame: 2009-2017
    • Statistical analysis using Chi-square test and binary logistic regression
  • The relationship between the choice of procedure and the tumor’s histological grade (using the Nottingham Histologic Score system)
    • Time Frame: 2009-2017
    • Statistical analysis using Chi-square test and binary logistic regression
  • The relationship between the choice of procedure and the tumor’s receptor status (whether it is positive for estrogen, progesterone, and/or human epidermal growth factor receptor 2)
    • Time Frame: 2009-2017
    • Statistical analysis using Chi-square test and binary logistic regression
  • The relationship between the choice of procedure and having preoperative magnetic resonance imaging of the breast and its findings
    • Time Frame: 2009-2017
    • Statistical analysis using Chi-square test and binary logistic regression

Participating in This Clinical Trial

Inclusion Criteria

  • Female, diagnosed with breast cancer, underwent surgery on the breast tumor in King Abdulaziz University Hospital Exclusion Criteria:

  • Patients with metastatic breast cancer or recurrence of the cancer before the surgery

Gender Eligibility: Female

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • King Abdulaziz University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Zuhoor K. AL-Sharif, Professor – King Abdulaziz University

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