Identification of Allergen-reactive Antibodies in the Blood of Pollen Allergic Patients

Overview

The project examines the hypothesis that monoclonal allergen-neutralizing antibodies can be recombinantly produced from B lymphocytes isolated from pollen allergic patients. Patient samples suitable for antibody cloning are selected based on seroprofiling for the respective allergens. The study aims at isolating lymphocytes from patients with potential allergen-neutralizing IgG in serum and to clone antibodies from antibody gene sequences obtained from B cells of those patients.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: September 30, 2024

Interventions

  • Other: blood withdrawal
    • Blood withdrawal

Clinical Trial Outcome Measures

Primary Measures

  • Antibody profiling
    • Time Frame: October 2018 – September 2021
    • Analysis and IgG profiling of specific antibodies binding major grass- and tree-pollen allergens in allergic patients.

Participating in This Clinical Trial

Inclusion Criteria

  • History of allergic rhinitis, conjunctivitis or asthma due to sensitization to grass- or birch Allergens – Male or female patients older than 18 years – Written informed consent for providing blood and also to allow experimental manipulation Exclusion Criteria:

  • Age < 18 years – Any corticosteroids within the last three days – Oral corticosteroid therapy within the last ten days – Parenteral depot corticosteroids within the last three months

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Mabylon AG
  • Provider of Information About this Clinical Study
    • Sponsor

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.