Clinical and Live Birth Rates After Following Long Antagonist Protocol Versus Long Agonist Protocol
Overview
A prospective study of the evaluation of the clinical IVF (in vitro fertilization) results after following Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus following Long Agonist protocol
Full Title of Study: “Clinical and Live Birth Rates After Controlled Ovarian Stimulation With the Long Antagonist Protocol Versus the Long Agonist Protocol”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: June 30, 2021
Detailed Description
A prospective study of the clinical results in women who followed the Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus women who followed Long Agonist protocol, in an In Vitro Fertilization (IVF) try. In particular, the Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR) were estimated for the two groups of patients. The number of the formed blastocysts was also measured in each group of patients.
Interventions
- Diagnostic Test: Clinical Pregnancy Rate
- The Clinical Pregnancy, Live Birth Rate and Blastulation Rate according to the protocol of COS
Arms, Groups and Cohorts
- Long Antagonist Protocol
- Clinical Pregnancy Rate, Live Birth Rate and Blastulation Rate of patients who followed Long Antagonist Protocol for Controlled Ovarian Stimulation.
- Long Agonist Protocol
- Clinical Pregnancy Rate and Live Birth Rates and Blastulation Rate of patients who followed Long Agonist Protocol for Controlled Ovarian Stimulation.
Clinical Trial Outcome Measures
Primary Measures
- Clinical Pregnancy Rate according to stimulation protocol
- Time Frame: 6 weeks to 42 weeks after embryo transfer
- Clinical Pregnancy Rate according to stimulation protocol
- Number of formed blastocysts in each group of patients
- Time Frame: 5 days after the OPU day
- The number of the formed blastocysts in each group of patients according to the COS protocol
Secondary Measures
- Live Birth Rate according to stimulation protocol
- Time Frame: 6 weeks to 42 weeks after embryo transfer
- Live Birth Rate according to stimulation protocol
Participating in This Clinical Trial
Inclusion Criteria
- primary infertility – age 18-39 years; body mass index (BMI) 18-29kg/m2; – regular menstrual cycle of 26-35days, – presumed to be ovulatory; – early follicular- phase serum concentration of FSH within normal limits (1-12 IU/l). Exclusion Criteria:
- women with diabetes and other metabolic disease – women with heart disease, QT prolongation,heart failure – elevated liver enzymes, liver failure, hepatitis – women with inflammatory or autoimmune disease – abnormal karyotype; – polycystic ovarian syndrome, – endometriosis stage III/IV; – history of being a 'poor responder', – defined as >20 days of gonadotrophin in a previous stimulation cycle, or any previous cancellation of a stimulation cycle due to limited follicular response, or development of less than 4 follicles 15 mm in a previous stimulation cycle; history of recurrent miscarriage; severe OHSS in a previous stimula- tion cycle or any contraindication for the use of gonadotrophins.
Gender Eligibility: Female
Minimum Age: 18 Years
Maximum Age: 39 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Assisting Nature
- Provider of Information About this Clinical Study
- Principal Investigator: Papanikolaou Evaggelos, Papanikolaou Evaggelos, MD, PhD, Fertility Specialist, Scientific Director at Assisting Nature IVF Clinic – Assisting Nature
- Overall Official(s)
- Evaggelos Papanikolaou, MD, PhD, Principal Investigator, Assisting Nature
- Robert Najdecki, MD, PhD, Principal Investigator, Assisting Nature
- Overall Contact(s)
- Evaggelos Papanikolaou, MD,PhD, 00302310424294, drvagpapanikolaou@yahoo.gr
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