Internal Jugular Vein Distensibility and Pleth Variability Index(PVI) for Evaluating Fluid Responsiveness

Overview

Assessment of intravascular volume status is crucial in order to predict the efficacy of volume status in major abdominal surgery. The aim of the study is to verify the feasibility and usefulness of the internal jugular vein distensibility index as an adjunct to the pleth variebility index(PVI) to predict fluid responsiveness in major abdominal surgery.

Full Title of Study: “Internal Jugular Vein Distensibility and Pleth Variability Index for Evaluating Fluid Responsiveness”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: September 30, 2018

Detailed Description

Forty patients above age 18 and ASA status I-III who are undergoing major abdominal surgery will be enrolled in the study. patients with right heart failure, arrythmia, severe valve stenosis or regurgitation will be excluded. After induction of general anesthesia, when the patients are hemodynamically stabilised, PVI and jugular vein distensibility will be calculated and recorded. after volume load with 500 ml gel infusion(in 15 min), measurements will be repeated within 10 minutes and recorded. Patients will be allocated to 2 groups according to the change in mean arterial pressure(MAP) after volume expansion: Responders will be defined as an increase in MAP by >; while nonresponders will be defined as an increase in MAP < or decrease in MAP.

Interventions

  • Procedure: Assessment of fluid responsiveness
    • assessment of intravascular volume status using pleth variebility index and internal jugular vein distensibility in major abdominal surgery

Arms, Groups and Cohorts

  • fluid responsiveness
    • Assessment of fluid responsiveness using pleth variebility index and jugular vein distensibility in patients undergoing major abdominal surgery

Clinical Trial Outcome Measures

Primary Measures

  • number of patients with significant change in VJI distensibility and pleth variebility index
    • Time Frame: during surgery at day 0
    • volume responders with significant change in jugular vein distensibility and pleth variebility index

Participating in This Clinical Trial

Inclusion Criteria

  • American Society of Anesthesiologists(ASA) physical status I-III patients – patients undergoing major abdominal surgery Exclusion Criteria:

  • arrythmia – severe right ventricle failure

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Tepecik Training and Research Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: MELTEM CAKMAK, Anesthesiologist – Tepecik Training and Research Hospital
  • Overall Official(s)
    • Yucel Karaman, ass. prof, Study Chair, Tepecik TRH

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