Hyperglycemia, Exercise, and Endothelial Function

Overview

The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.

Full Title of Study: “Effect of Short-Term Glucose Loading on Vascular Function”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: October 21, 2019

Detailed Description

Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Interventions

  • Behavioral: GLU+EX
    • Subjects will complete 45 minutes of recumbent cycling at 60-65% of age-predicted maximal heart rate five times over seven days while ingesting a 75g glucose beverage three times daily.
  • Dietary Supplement: GLU
    • Subjects will consume a 75g glucose beverage three times daily over a seven-day period.

Arms, Groups and Cohorts

  • Experimental: GLU+EX
    • Subjects will consume a 75g glucose beverage three times daily for seven days while participating in five structured aerobic exercise sessions throughout the experimental protocol.
  • Active Comparator: GLU
    • Subjects will consume a 75g glucose beverage three times daily for seven days without participating in structured aerobic exercise.

Clinical Trial Outcome Measures

Primary Measures

  • Change in Vascular Endothelial Function
    • Time Frame: Before and after the seven-day intervention in both groups.
    • Brachial artery flow-mediated dilation (%), measured via Doppler ultrasound, will be assessed before and after the intervention.

Secondary Measures

  • Central Blood Pressure
    • Time Frame: Before and after the seven-day intervention in both groups.
    • Aortic blood pressure will be derived from radial artery pressure wave measurements (via applanation tonometry) during resting conditions.

Participating in This Clinical Trial

Inclusion Criteria

  • Healthy young men 18-35 years of age. Exclusion Criteria:

  • Hypertension, – Hyperlipidemia, – Smoking, – Heart disease, – Chest pain upon exertion, – Previous heart surgeries or history of arrhythmias, – Diabetes, – Obesity (body mass index ≥30kg/m2), – Kidney disease, – Pulmonary disease, – Autonomic disorders, – Individuals whom engage in structured exercise (≥30min, ≥2d/wk), – Current use of medications which influence outcome measures

Gender Eligibility: Male

Minimum Age: 18 Years

Maximum Age: 35 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Iowa
  • Provider of Information About this Clinical Study
    • Principal Investigator: Darren P Casey, Assistant Professor – University of Iowa

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