Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts

Overview

Comparison the results of skin prick testing and Intradermal skin test result of local and imported insect allergen extracts in patients with serious insect sting allergy reactions

Full Title of Study: “Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts in Patients With Severe Insect Sting Allergy”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Diagnostic
    • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: May 30, 2019

Detailed Description

The patients with serious insect sting allergy reactions were evaluated and skin prick test and intradermal test with local and imported insect allergen extracts were performed. Specific IgE for insects was also performed. The results of skin prick testing and Intradermal skin test of local and imported insect allergen extracts were compared. The results also compared with specific IgE to insects

Interventions

  • Diagnostic Test: Local insect allergen extracts skin test
    • Every patient received both local and commercial insect allergen extracts but in blinded methods

Arms, Groups and Cohorts

  • Active Comparator: Skin test with local extract
    • Skin prick test and intradermal test with local stinging insect allergen extracts that develop in Immunological division of Siriraj hospital, mahidol University
  • Sham Comparator: Skin test with commercial extract
    • Skin prick test and intradermal test with commercial stinging insect allergen extracts that order from ALK company

Clinical Trial Outcome Measures

Primary Measures

  • Comparison of positive skin test results of local and commercial insect allergen extracts
    • Time Frame: 1 year
    • Measure wheal size of skin test of local and commercial insect allergen extracts then compare the positive result and wheal size between local and commercial extracts.

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with severe insect allergy reaction – Allow being done skin test and blood foe specific IgE Exclusion Criteria:

  • Serious systemic diseases – severe asthma – pregnant or nursing – severe and extended skin lesion

Gender Eligibility: All

Minimum Age: 5 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Mahidol University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Nualanong Visitsunthorn, Professor – Mahidol University
  • Overall Official(s)
    • Nualanong Visitsunthorn, MD, Principal Investigator, Siriraj hospital, Mahidol University, Bangkok Thailand

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