Opioid Use After Traumatic Injury in Adolescents

Overview

Currently, 1 in 8 adolescents continue to receive prescription opioids a year or more after injury. By longitudinally surveying patients, we can identify risk factors and pathways to nonmedical opioid use. Furthermore, by assessing whether pain management and mental health treatment after injury moderates sustained opioid use and prescription opioid misuse, we can create targeted interventions to reduce future nonmedical opioid use in adolescents.

Full Title of Study: “A Prospective Survey of Opioid Use After Traumatic Injury in Adolescents”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: March 31, 2023

Detailed Description

This is a prospective cohort study that will follow participants for 2 years and administer surveys to adolescents both traumatically injured and uninjured on prescription opioid usage, substance use, utilization of pain management and mental health services, and mental and physical health condition conditions.

Arms, Groups and Cohorts

  • Traumatically Injured Adolescent
  • Not Traumatically Injured Adolescent

Clinical Trial Outcome Measures

Primary Measures

  • Prospectively determine drivers of sustained opioid use and prescription opioid misuse.
    • Time Frame: 2 years

Secondary Measures

  • Identify patient-reported factors for sustained prescription opioid use, including chronic pain and mental health conditions such as PTSD, depression, anxiety, and sleep disorders.
    • Time Frame: 2 years
  • Assess behavioral, social, and clinical predictors of prescription opioid misuse and nonmedical opioid use by longitudinally surveying injured adolescents.
    • Time Frame: 2 years
  • Qualitatively determine patients’ motives for continued opioid therapy, prescription opioid misuse, and nonmedical opioid use by interviewing injured adolescents.
    • Time Frame: 2 years
  • Analyze genetic information, obtained via saliva sample and the company 23andMe, from each participant to determine if some people are more likely to use more pain medication than others or respond better to certain pain medications.
    • Time Frame: 2 years

Participating in This Clinical Trial

Inclusion Criteria

  • Patient is 12-20 years of age – Adolescent admitted for trauma OR adolescent with no recent trauma – English speaking – Consent can be obtained from a parent or guardian Exclusion Criteria:

  • Patients with severe brain injuries or other injuries that prevent survey participation

Gender Eligibility: All

Minimum Age: 12 Years

Maximum Age: 20 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Indiana University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Olena Mazurenko, Associate Professor of Health Policy – Indiana University

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.