Effects of Resistin on Neutrophil Function

Overview

To assess the effect of resistin on neutrophil migration and intracellular bacterial killing

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: September 1, 2019

Clinical Trial Outcome Measures

Primary Measures

  • intracellular bacterial killing, assessed by number of colonies of bacterial growth following neutrophil exposure to bacteria and resistin
    • Time Frame: 6 months

Participating in This Clinical Trial

Inclusion Criteria

  • age ≥ 18 – gender: male or female Exclusion Criteria – Adults who are unable to provide informed consent themselves – History of chronic kidney disease as defined by estimated glomerular filtration rate (GFR) <60 ml/min prior to cardiogenic shock – Patients with hematologic malignancies – Pregnant women – Patient/surrogate is not fluent in English – Long-term immunosuppressive therapy – Prisoner – Patients on pre-existing continuous reno-renal therapy (CRRT) or intermittent hemodialysis (IHD

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 100 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Milton S. Hershey Medical Center
  • Provider of Information About this Clinical Study
    • Principal Investigator: Anthony Bonavia, Assistant Professor, Department of Anesthesiology – Milton S. Hershey Medical Center
  • Overall Official(s)
    • Anthony Bonavia, MD, Principal Investigator, Penn State Milton S Hershey Med Ctr

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