Fatigability and Physical Performance: Effects of Resistance Training Variables Manipulation

Overview

This study evaluate whether resistance training variables modulate the fatigability (power-duration relationship) and physical performance in adults and older adults

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Prevention
    • Masking: None (Open Label)
  • Study Primary Completion Date: September 30, 2018

Detailed Description

The resistance training variables manipulation is utilized for maximize the results of resistance training. However it is unclear whether the resistance training variables manipulation modulates the fatigability (i.e. power-duration relationship) and whether this explains the improvement on physical performance (i.e. gait speed, sit-to-stand and timed up and go tests).

Interventions

  • Other: Resistance training, LL
    • In LL, the postmenopausal women will be submitted to 12 weeks of Resistance training with moderate volume (i.e. three sets per exercise) and low load (i.e. 30% of one repetition maximum)
  • Other: Resistance training, HL
    • In HL, the postmenopausal women will be submitted to 12 weeks of Resistance training with moderate volume (i.e. three sets per exercise) and high load (i.e. 80% of one repetition maximum)
  • Other: Resistance training, HVHL
    • In HVHL, the postmenopausal women will be submitted to 12 weeks of Resistance training with high volume (i.e. six sets per exercise) and hig load (i.e. 80% of one maximum repetition)
  • Other: Control group, CG
    • The CG groups do not will performed the exercise.

Arms, Groups and Cohorts

  • Experimental: Lower load resistance training (LL)
    • In the LL group, postmenopausal women will perform the resistance training with moderate volume (i.e. three sets per exercise performed until or close to failure) and low load (i.e. 30% of 1RM)
  • Experimental: Higher load resistance training (HL)
    • In the HL group, postmenopausal women will perform the resistance training with moderate volume (i.e. three sets per exercise performed until or close to failure) and high load (i.e. 80% of 1RM)
  • Experimental: Higher volume resistance training (HVHL)
    • In the HVHL group, postmenopausal women will perform the resistance training with high volume (i.e. six sets per exercise performed until or close to failure) and high load (i.e. 80% of 1RM)
  • Other: Control group, (CG)
    • In CG, the postmenopausal women group will not perform exercise

Clinical Trial Outcome Measures

Primary Measures

  • Fatigability
    • Time Frame: Changes in fatigability measure (e.g. baseline and after 12 weeks of intervention)
    • The fatigability will be evaluate by 60 maximum voluntary isometric contractions (3 s contraction, 2 s rest) in knee extensors at 70 degree.

Secondary Measures

  • Physical Performance
    • Time Frame: Changes in physical performance measure (e.g. baseline and after 12 weeks of intervention)
    • The physical performance will be evaluate by gait speed tests (e.g. 10m walking at usual and fast pace, 400m walk at usual and fast pace).

Participating in This Clinical Trial

Inclusion Criteria

  • Postmenopausal women (>12 months amenorrhea) with age above or equal 50 years old. – No hormone therapy or phytoestrogens Exclusion Criteria:

  • No-drinker alcohol (no alcohol intake whatsoever in their diet); – Non- smokers; – Hypertensive with uncontrolled blood pressure values; – Diabetic with uncontrolled glycemia; – Presence of arthropathies; – Presence of myopathies; – Skeletal musculotendinous disorder.

Gender Eligibility: Female

Minimum Age: 50 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Universidade Federal do Triangulo Mineiro
  • Provider of Information About this Clinical Study
    • Principal Investigator: Fábio Lera Orsatti, Principal Investigator – Universidade Federal do Triangulo Mineiro
  • Overall Official(s)
    • Fabio L Orsatti, PhD, Principal Investigator, Federal University of Triangulo Mineiro
  • Overall Contact(s)
    • Fabio L Orsatti, PhD, +55343700-6634, fabiorsatti@gmail.com

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