Clinical Feature and Treatment of Microsporidial Keratoconjunctivitis

Overview

The purpose of this project was to analysis the causes, pathogenesis, diagnostic modalities and treatment outcomes of microsporidial keratoconjunctivitis.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: May 31, 2019

Detailed Description

Microsporidia comprise a diverse group of obligate spore-forming intracellular eukaryotic pathogens first described in immunocompromised patients. Many species of microsporidia are found in aquatic environments, and they are considered as waterborne pathogens.Microsporidia are opportunistic pathogens that are reported to cause infections in various organs, including the eyes. The ocular appearance of this infection can manifest as corneal stromal keratitis or a superficial punctate keratoconjunctivitis. In particular, the characteristic feature of microsporidial keratoconjunctivitis is multiple whitish, slightly elevated epithelial lesions in conjunction with acute conjunctivitis. Awareness of microsporidial keratoconjunctivitis is increasing, and the number of cases reported is on the rise. This study was a retrospective case series of patients diagnosed as microsporidial keratoconjunctivitis. The purpose of this project was to analysis the causes, pathogenesis, diagnostic modalities and treatment outcomes of microsporidial keratoconjunctivitis

Clinical Trial Outcome Measures

Primary Measures

  • Full chart records of the patients who diagnosed as microsporidial keratoconjunctivitis
    • Time Frame: 2018/6/1-2019/5/31
    • Charts of all patients diagnosed as microsporidial keratoconjunctivitis between January, 2008 and April, 2018 at National Taiwan University Hospital were reviewed.

Participating in This Clinical Trial

Inclusion Criteria

  • Patients diagnosed as microsporidial keratoconjunctivitis Exclusion Criteria:

  • Patients diagnosed as bacterial or viral keratoconjunctivitis

Gender Eligibility: All

Minimum Age: 7 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • National Taiwan University Hospital
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • I-Jong Wang, Principal Investigator, National Taiwan University Hospital
  • Overall Contact(s)
    • I-Jong Wang, 886-2-23123456, ijong@ntu.edu.tw

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