Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise

Overview

Strength training is commonly used as an intervention to increase muscle mass, thus improving a person's ability to undertake activities of daily living, or enhance athletic performance. The strength training regimen itself, while ultimately having beneficial effects, causes muscle fibers to be damaged, which the body has to recover from. As the body recovers, it rebuilds the muscle tissue and after multiple consecutive bouts of strength training, the muscle eventually becomes larger and stronger. Thus, it is the recovery from strength training exercise that ultimately determines how well the body adapts. Where inadequate recovery could eventually lead to overtraining and/or injury, optimizing the recovery process from strength training could maximize strength training adaptations. This concept of optimizing recovery has led to development of many supplements, including antioxidants, which may reduce the damage associated with strength training activities and therefore enhance positive adaptations. The purpose of this study is to assess the ability of a polyphenol rich supplementation to aid the recovery process from a demanding bout of resistance exercise

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Basic Science
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: August 2018

Interventions

  • Dietary Supplement: Tart Cherry
    • NordicCherry Tart Cherry Extract Powder 500 mg from Specnova, inc
  • Other: Placebo Oral Capsule [CEBOCAP]
    • Rice flour

Arms, Groups and Cohorts

  • Placebo Comparator: Placebo
    • Rice flour capsule
  • Active Comparator: Polyphenol Rich Supplement
    • NordicCherry Tart Cherry Extract Powder 500 mg in capsule form

Clinical Trial Outcome Measures

Primary Measures

  • Assessment of Oxidative Stress
    • Time Frame: 7 weeks
    • Blood analyses will be used, 8 mL of blood will be taken from the participant six times per condition. The blood will be centrifuged to separate the serum/ plasma and analyzed by enzyme- linked immunosorbent assay (ELISA) for c- reactive protein and creatine kinase, and oxidative damage

Secondary Measures

  • Muscle soreness
    • Time Frame: 7 weeks
    • Subjects will mark a line on a 10cm scale that corresponds to the amount of muscular soreness they currently perceive
  • Vertical Jump Performance
    • Time Frame: 7 weeks
    • Subjects will be instructed to stand on a NeuroCom Balance Manager forceplate with hands on hips. Subjects will then be instructed to perform 3 consecutive vertical jumps, as high as possible with minimal time between jumps. The jumps will later be assessed for power production.

Participating in This Clinical Trial

Inclusion Criteria

  • 6 months of resistance training experience with barbel back squat exercise Exclusion Criteria:

  • Not currently taking any antioxidant supplements, not currently using any hormone replacement therapy or anabolic androgenic steroids.

Gender Eligibility: Male

Must be male

Minimum Age: 21 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Jacksonville University
  • Collaborator
    • Specnova, inc
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Heather Hausenblaus, Principal Investigator, Jacksonville University
  • Overall Contact(s)
    • Heather Hausenblaus, 904-256-7975, hhausen@ju.edu

References

Reid MB. Invited Review: redox modulation of skeletal muscle contraction: what we know and what we don't. J Appl Physiol (1985). 2001 Feb;90(2):724-31. doi: 10.1152/jappl.2001.90.2.724.

Citations Reporting on Results

Alessio HM, Goldfarb AH, Cutler RG. MDA content increases in fast- and slow-twitch skeletal muscle with intensity of exercise in a rat. Am J Physiol. 1988 Dec;255(6 Pt 1):C874-7. doi: 10.1152/ajpcell.1988.255.6.C874.

Blair SN, Cheng Y, Holder JS. Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc. 2001 Jun;33(6 Suppl):S379-99; discussion S419-20. doi: 10.1097/00005768-200106001-00007.

Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 2008 Oct;88(4):1243-76. doi: 10.1152/physrev.00031.2007.

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