Oxygenation and Perfusion in Patients With Acute Migraine Attacks

Overview

The aim of the study is to retrospectively evaluate brain perfusion and oxygenation in acute migraine attacks. Magnetic resonance perfusion and susceptibility weighted imaging are the technics to measure perfusion and oxygenation respectively.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: April 30, 2018

Detailed Description

The aim of the study is to demonstrate a possible correlation between areas of hypoperfusion and prominent cortical veins during migraine attacks. These focal ares of altered vascular supply of the brain will be evaluated for correlation with topograhy of symptoms.

Clinical Trial Outcome Measures

Primary Measures

  • Focal cerebral hypoperfusion and elevated oxygenation in acute migraine attack
    • Time Frame: Patients, who are admitted to hospital, undergo magnetic resonance imaging within 5 days of migraine attack; time frame: symptoms to imaging : 5 days;
    • Focal cerebral hypoperfusion and elevated oxygenation in acute migraine attack, measured with visual scores on imaging, using a consensus between two readers

Participating in This Clinical Trial

Inclusion Criteria

final clinical diagnosis of migraine Exclusion Criteria:

brain tumors, seizures/epilepsy, confirmed cerebral infarct from cerebral atery occlusion, sinus vein thrombosis;

Gender Eligibility: All

Minimum Age: 6 Years

Maximum Age: 80 Years

Investigator Details

  • Lead Sponsor
    • Insel Gruppe AG, University Hospital Bern
  • Provider of Information About this Clinical Study
    • Sponsor

Citations Reporting on Results

Bosemani T, Burton VJ, Felling RJ, Leigh R, Oakley C, Poretti A, Huisman TA. Pediatric hemiplegic migraine: role of multiple MRI techniques in evaluation of reversible hypoperfusion. Cephalalgia. 2014 Apr;34(4):311-5. doi: 10.1177/0333102413509432. Epub 2013 Oct 18.

Charles A, Brennan KC. The neurobiology of migraine. Handb Clin Neurol. 2010;97:99-108. doi: 10.1016/S0072-9752(10)97007-3.

Fedak EM, Zumberge NA, Heyer GL. The diagnostic role for susceptibility-weighted MRI during sporadic hemiplegic migraine. Cephalalgia. 2013 Nov;33(15):1258-63. doi: 10.1177/0333102413491027. Epub 2013 Jun 13.

Floery D, Vosko MR, Fellner FA, Fellner C, Ginthoer C, Gruber F, Ransmayr G, Doerfler A, Uder M, Bradley WG. Acute-onset migrainous aura mimicking acute stroke: MR perfusion imaging features. AJNR Am J Neuroradiol. 2012 Sep;33(8):1546-52. doi: 10.3174/ajnr.A3020. Epub 2012 Apr 19.

Forster A, Wenz H, Kerl HU, Brockmann MA, Groden C. Perfusion patterns in migraine with aura. Cephalalgia. 2014 Oct;34(11):870-6. doi: 10.1177/0333102414523339. Epub 2014 Feb 19.

Kao HW, Tsai FY, Hasso AN. Predicting stroke evolution: comparison of susceptibility-weighted MR imaging with MR perfusion. Eur Radiol. 2012 Jul;22(7):1397-403. doi: 10.1007/s00330-012-2387-4. Epub 2012 Feb 10.

Launer LJ, Terwindt GM, Ferrari MD. The prevalence and characteristics of migraine in a population-based cohort: the GEM study. Neurology. 1999 Aug 11;53(3):537-42. doi: 10.1212/wnl.53.3.537.

Mourand I, Menjot de Champfleur N, Carra-Dalliere C, Le Bars E, Roubertie A, Bonafe A, Thouvenot E. Perfusion-weighted MR imaging in persistent hemiplegic migraine. Neuroradiology. 2012 Mar;54(3):255-60. doi: 10.1007/s00234-011-0946-z. Epub 2011 Aug 11.

Planche V, Chassin O, Leduc L, Regnier W, Kelly A, Colamarino R. Sturge-Weber syndrome with late onset hemiplegic migraine-like attacks and progressive unilateral cerebral atrophy. Cephalalgia. 2014 Jan;34(1):73-7. doi: 10.1177/0333102413505237. Epub 2013 Sep 17.

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