Individualized Positive End-expiratory Pressure Evaluation Using the Intratidal Compliance-volume Profile in Children

Overview

The investigators assess the changes in respiratory compliance according to different levels of positive end expiratory pressure (PEEP) in children under general anesthesia. In addition, the investigators evaluate the intratidal compliance-volume profile at each PEEP level and determine the optimal PEEP level during anesthesia.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: November 20, 2019

Interventions

  • Procedure: Positive end expiratory pressure (PEEP)
    • The different levels of PEEP, 5 cmH2O, 8 cmH2O and 12 cmH2O, are applied serially. Mean respiratory compliance and intratidal compliance-volume profile are evaluated.

Arms, Groups and Cohorts

  • Experimental: Children
    • Children who receive elective surgery under general anesthesia and are supported by mechanical ventilation

Clinical Trial Outcome Measures

Primary Measures

  • Mean respiratory compliance
    • Time Frame: During 15 minutes after applying each level of PEEP
    • Mean static and dynamic compliance

Secondary Measures

  • Compliance profile
    • Time Frame: During 15 minutes after applying each level of PEEP
    • We will determine Intratidal compliance-volume profile using the changes in compliance over time –> I, merely increasing compliance profile; IH, increasing turning into horizontal compliance profile; D, merely decreasing compliance profile; HD, horizontal turning into decreasing compliance profile; IHD, increasing turning into horizontal and further turning into decreasing compliance profile If compliance profile is I, the PEEP is low. On the other hand, compliance profile is D, PEEP level is considered to be high.
  • Airway resistance
    • Time Frame: During 15 minutes after applying each level of PEEP
    • Mean airway resistance

Participating in This Clinical Trial

Inclusion Criteria

  • Children undergoing surgery more than 1 hour under general anesthesia – American Society Anesthesiologist physical status I, II Exclusion Criteria:

  • History of lung resection – History of bronchopulmonary dysplasia or respiratory distress syndrome – Abnormalities in chest radiography – Laparoscopic surgery – Abdominal surgery

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: 6 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Seoul National University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jin-Tae Kim, Professor – Seoul National University Hospital
  • Overall Official(s)
    • Jin-Tae Kim, PhD, Principal Investigator, Seoul National University Hospital, Seoul National University College of Medicine

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