Clinic Registry Study of Optic Neuromyelitis Spectrum Disease in China

Overview

In 1894, Devic first proposed the concept of neuromyelitis optica(NMO). NMO is an inflammatory demyelinating disease that selectively affects the central nervous system of the optic nerve and spinal cord.In 2004, Lennon and other persons found highly specific AQP4(aquaporin 4)antibodies in NMO patients'sera, and further differentiated between NMO and MS, confirming that NMO is an independent disease.At present, NMO has been widely recognized as an idiopathic and severe demyelinating disease of the central nervous system.In 2015, the international NMO diagnostic team developed the diagnostic criteria based on highly specific AQP4 antibodie.Up to now, in China, there is no data on the number of NMOSD patients, the rate of misdiagnosis, the treatment methods, and the prognosis.This study is committed to build China's NMOSD big data platform to provide the basis for diagnosis, treatment and prognosis of the disease.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: April 2020

Interventions

  • Diagnostic Test: serum AQP4-antibody testing method
    • there are different methods of testing serum AQP4-antibody

Arms, Groups and Cohorts

  • positive
    • serum AQP4-antibody is positive
  • negtive
    • serum AQP4-antibody is negtive

Clinical Trial Outcome Measures

Primary Measures

  • misdiagnosis rate
    • Time Frame: 3 years
    • misdiagnosis rate of NMOSD

Participating in This Clinical Trial

Inclusion Criteria

1. more than 14 years old 2. Compliance with the diagnostic standard by the NMO International Diagnostic team in 2015 Exclusion Criteria:

1. less than 14 years old 2. NOT Compliance with the diagnostic standard by the NMO International Diagnostic team in 2015

Gender Eligibility: All

Minimum Age: 14 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Beijing Tongren Hospital
  • Provider of Information About this Clinical Study
    • Sponsor

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