Chinese FPD Registry

Overview

The purpose of the Chinese Familial Parkinson's disease Registry (CFPDR) is to develop a database of patients with familial Parkinson's disease (PD) in China.

Full Title of Study: “The Chinese Familial Parkinson’s Disease Registry”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: February 1, 2027

Detailed Description

Parkinson's disease (PD) is the second most common disorder among degenerative neurological disease. Familial PD (FPD) has its unique clinical feature and genetic basis. We aim to establish a database of FPD,and characterize the clinical feature, genetic basis, environmental factors and their interactions FPD in China. Method: 1. Clinical feature will be measured by scales and neurological tests.Standard scales includes: Unified Parkinson's Disease Rating Scale(UPDRS), Hoehn-Yahr stages, NMSS, MMSE, PDSS(Parkinson disease sleep scales),Rapid Eye Movement Sleep Behaviour Disorder Questionnaire(RBDQ-HK),ESS(Epworth Sleepiness Scale),Rome III functional constipation scale,SCOPA-AUT (the Scale for Outcomes in PD for Autonomic Symptoms),PFS(Parkinson Fatigue Scale),CH-RLSq,Hyposmia rating scale(HRS)HAMILT depression scale,the 39-item Parkinson's Disease Questionnaire(PDQ-39),Freezing of gait scale(FOG),dyskinesia related scales, Wearing-off scale(WO) 2. Peripheral blood from patients and other members in family will be collected for familial PD genetic testing. 3. The environmental factors are exploded by questionnaires including smoking,drinking, pesticide and heavy metals.

Clinical Trial Outcome Measures

Primary Measures

  • Database of Familial Parkinson’s disease
    • Time Frame: 10 years
    • To collect 1500 patients with familial Parkinson’s disease and establish the database of Familial Parkinson’s disease (FPD) in mainland China.
  • Risk Factors
    • Time Frame: 10 years
    • To characterize clinical feature and environmental factors among Chinese familial parkinson’s disease
  • Genetic Basis
    • Time Frame: 10 years
    • To characterize the genetic basis of Chinese FPD and detect clinically relevant genetic variants in these cases

Participating in This Clinical Trial

Inclusion Criteria

  • Clinical diagnosis of Parkinson's disease, and either family history of Parkinson's disease (first or second degree family member affected by Parkinson's disease) AND/OR Clinical diagnosis of Parkinson's disease and their parents are close relatives(First or second degree family member of an Index Case, affected or unaffected by Parkinson's disease). Exclusion Criteria:

  • Lack of capacity to consent to participate in the project

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Investigator Details

  • Lead Sponsor
    • Xiangya Hospital of Central South University
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Contact(s)
    • Jifeng Guo, Ph.D., +8613974936815, guojifeng2003@163.com

References

Yan W, Tang B, Zhou X, Lei L, Li K, Sun Q, Xu Q, Yan X, Guo J, Liu Z. TMEM230 mutation analysis in Parkinson's disease in a Chinese population. Neurobiol Aging. 2017 Jan;49:219.e1-219.e3. doi: 10.1016/j.neurobiolaging.2016.10.007. Epub 2016 Oct 11.

Yang Y, Tang BS, Weng L, Li N, Shen L, Wang J, Zuo CT, Yan XX, Xia K, Guo JF. Genetic Identification Is Critical for the Diagnosis of Parkinsonism: A Chinese Pedigree with Early Onset of Parkinsonism. PLoS One. 2015 Aug 21;10(8):e0136245. doi: 10.1371/journal.pone.0136245. eCollection 2015.

Li K, Tang BS, Liu ZH, Kang JF, Zhang Y, Shen L, Li N, Yan XX, Xia K, Guo JF. LRRK2 A419V variant is a risk factor for Parkinson's disease in Asian population. Neurobiol Aging. 2015 Oct;36(10):2908.e11-5. doi: 10.1016/j.neurobiolaging.2015.07.012. Epub 2015 Jul 11.

Citations Reporting on Results

Liu Z, Guo J, Li K, Qin L, Kang J, Shu L, Zhang Y, Wei Y, Yang N, Luo Y, Sun Q, Xu Q, Yan X, Tang B. Mutation analysis of CHCHD2 gene in Chinese familial Parkinson's disease. Neurobiol Aging. 2015 Nov;36(11):3117.e7-3117.e8. doi: 10.1016/j.neurobiolaging.2015.08.010. Epub 2015 Aug 15.

Guo JF, Li K, Yu RL, Sun QY, Wang L, Yao LY, Hu YC, Lv ZY, Luo LZ, Shen L, Jiang H, Yan XX, Pan Q, Xia K, Tang BS. Polygenic determinants of Parkinson's disease in a Chinese population. Neurobiol Aging. 2015 Apr;36(4):1765.e1-1765.e6. doi: 10.1016/j.neurobiolaging.2014.12.030. Epub 2015 Jan 6.

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