A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy

Overview

This retrospective observational study is designed to assess the response to treatment with ocular acupuncture and its relative factors, in terms of diplopia status, ocular motility differences, and clinical features, in ocular motor nerve palsy patients. During this study, a retrospective data collection will be carried out using the information contained in the medical record of aimed patients, provided that the treatment with ocular acupuncture.

Full Title of Study: “A Retrospective Study to Investigate the Efficacy and Relative Factors of Ocular Acupuncture in Ocular Motor Nerve Palsy Patients”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: May 15, 2018

Interventions

  • Other: Ocular acupuncture
    • Patient’s skin located in the extraocular muscles projection area is routinely disinfected. A diameter of 0.20 mm and length of 25 mm needle is inserted slowly. Piercing depth is about 20mm. The electropuncture apparatus is used, each group of electrodes are distinguished with different colors of wires to generate current stimulations of current 1.0~1.5 milliampere (mA), voltage 9 volt(V), frequency 1.5 hertz (Hz), and duration of 40 minutes.

Arms, Groups and Cohorts

  • Ocular motor nerve palsy treated by ocular acupuncture
    • Ocular motor nerve palsy patients who received ocular acupuncture treatment

Clinical Trial Outcome Measures

Primary Measures

  • Clinical efficacy rate (Cure, Effective and Invalid)
    • Time Frame: Through study completion, an average of 1 month.
    • Clinical efficacy rate (Cure, Effective and Invalid) assessed by investigator’s discretion. Efficacy rate is calculated as number of patients with Cure and effective proportional to number of all cases.

Secondary Measures

  • Diplopia angle
    • Time Frame: Through study completion, an average of 2 weeks.
    • Patient’s diplopia angle obtained by retrospective chart review.
  • Eyeball movement distance
    • Time Frame: Through study completion, an average of 2 weeks.
    • Patient’s eyeball movement distance obtained by retrospective chart review.
  • Distance between upper and lower eyelid.
    • Time Frame: Through study completion, an average of 2 weeks.
    • Patient’s distance between upper and lower eyelid obtained by retrospective chart review.

Participating in This Clinical Trial

Inclusion Criteria

  • Age over 18 years old – Patient who received at lease 1 times of ocular acupuncture treatment – Patient who received full set of ophthalmology & neurology assessment pre- and post-treatment. Exclusion Criteria:

  • patient who combined with extraocular muscles diseases, eg.thyroid eye disease – patient who underwent periocular surgery – patient who combined with congenital ocular motor nerve palsy, eg. Brown syndrome. – patient who had untreated condition which may lead to ocular motor nerve palsy such as intracranial aneurysm and brain tumor.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • First Affiliated Hospital of Harbin Medical University
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Contact(s)
    • lingyun zhou, PHD, 85556000, no1zhly@163.com

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