Bariatric Surgery and Pharmacokinetics of Atomoxetine

Overview

Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on atomoxetine are investigated.

Full Title of Study: “Bariatric Surgery and Pharmacokinetics of Atomoxetine: BAR-MEDS Atomoxetine”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: October 2026

Interventions

  • Drug: Atomoxetine
    • Patients are tested for their normal prescription atomoxetine medication

Clinical Trial Outcome Measures

Primary Measures

  • Atomoxetine concentration in blood serum (area under curve (AUC))
    • Time Frame: From baseline to 1 year postoperatively

Participating in This Clinical Trial

Inclusion Criteria

  • Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway – Being a Norwegian citizen Exclusion Criteria:

  • Having previously undergone resections in the GI-tract

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Norwegian University of Science and Technology
  • Collaborator
    • St. Olavs Hospital
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Magnus Strømmen, MSc, Principal Investigator, St. Olavs University Hospital
  • Overall Contact(s)
    • Magnus Strømmen, MSc, 0047 72829970, magnus.strommen@stolav.no

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