Target Effect-site Concentration of Remifentanil in Transperineal Prostate Puncture

Overview

The research about the target effect-site concentration of remifentanil, inhibiting stress reaction of the perineal prostate puncture when Dexmedetomidine being continuous pumping

Full Title of Study: “The Research About the Target Effect-site Concentration of Remifentanil Inhibiting Stress Reaction of the Perineal Prostate Puncture When Dexmedetomidine Being Continuous Pumping”

Study Type

  • Study Type: Observational [Patient Registry]
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: February 2018

Detailed Description

Patients who were scheduled to undergo transperineal prostate puncture and biopsy were recruited into our study. In all patients, dexmedetomidine was injected at a bolus of 0.6 mg/kg and then continuously infused at 0.6 ug/kg/h using the conventional continuous microinfusion pump. the target Effect-site concentration of remifentanil was determined by sequential method. The first target effect-site concentration of remifentanil was set to 4.5ng/ml, the difference of adjacent target concentration was 0.5 ng/ml. Cardiovascular positive reaction was defined as the changes of heart rate or systolic blood pressure was more than 15% compared with baseline values, or body movement observed. The adjacent target concentration difference was adjusted to 0.2 ng/ml after 3 negative and positive reaction cycles. If the first had a cardiovascular positive reaction, the target concentration of remifentanil increased by a concentration gradient. Conversely, the target concentration of remifentanil decreased by a concentration gradient.

Interventions

  • Drug: Remifentanyl+Dexmedetomidine
    • In all patients, dexmedetomidine was injected at a bolus of 0.6 mg/kg and then continuously infused at 0.6 ug/kg/h using the conventional continuous microinfusion pump. the target Effect-site concentration of remifentanil was determined by sequential method.

Clinical Trial Outcome Measures

Primary Measures

  • the target effect-site concentration of remifentanil
    • Time Frame: intraoperative
    • the target Effect-site concentration of remifentanil was determined by sequential method.

Participating in This Clinical Trial

Inclusion Criteria

  • patients of perineal prostate puncture Exclusion Criteria:

  • sinus bradycardia or atrioventricular block serious heart, brain, lung, liver, kidney, and metabolic disease allergy for dexmedetomidine or opioid

Gender Eligibility: Male

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Chinese Medical Association
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Liu Yi, D.M, Study Director, Department of Anesthesiology, Changhai Hospital Shanghai, Shanghai, China, 200433
  • Overall Contact(s)
    • Yi Zhou, 13761293168, littlebaby89@163.com

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