Systematic Review and Meta-analysis of Cereal or Grain Consumption and Gastric Cancer

Overview

This project involved a systematic literature review of published trials of cereal or grain in relation to the risk of gastric cancer. Data was extracted from the publications on PubMed, EMBASE, Cochrane Library.A traditional meta-analysis, subgroup analysis, and heterogeneity was conducted on the extracted data.

Full Title of Study: “Cereal or Grain Consumption and Gastric Cancer Risk: a Systematic Review and Meta-analysis of Observational Studies”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: December 20, 2017

Detailed Description

Investigators searched PubMed, EMBASE, Cochrane Library for studies focusing on cereal or grain in relation to the risk of gastric cancer up to October 2017. Summary odd ratios (OR) and 95% confidence intervals (CI) were calculated by using either random effect models or fixed effect models according to the heterogeneity of included studies. Subgroup analysis, heterogeneity, and publication bias were also performed.

Interventions

  • Dietary Supplement: cereal or grain consumption
    • intake of cereal, whole grain, refined grain, and other grain of every day

Arms, Groups and Cohorts

  • gastric cancer

Clinical Trial Outcome Measures

Primary Measures

  • the relationship between overall cereal consumption and gastric cancer occurance
    • Time Frame: up to 2 years
    • perform a pooled analysis of included studies with OR through STATA 12.0

Secondary Measures

  • the relationship between whole grain and gastric cancer occurance
    • Time Frame: up to 2 years
    • perform a subgroup analysis to summarize the related OR through STATA 12.0
  • the relationship between refined grain and gastric cancer occurance
    • Time Frame: up to 2 years
    • perform a subgroup analysis to summarize the related OR through STATA 12.0
  • the relationship between other grain and gastric cancer occurance
    • Time Frame: up to 2 years
    • perform a subgroup analysis to summarize the related OR through STATA 12.0

Participating in This Clinical Trial

Inclusion Criteria

  • a case-control studies or a cohort study – investigate the association between cereal or grain intake and GC occurrence – report an odds ratio (OR) or relative risk (RR) with corresponding 95% confidence intervals (CI) – provide sufficient data to estimate OR or RR Exclusion Criteria:

  • Non-human studies – GC mortality-based cohort studies

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • West China Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Yong Zhou, associate chief physician – West China Hospital

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