Assessment of Change in Atherosclerotic Plaque by Serial CCTA

Overview

Assessment of Change in AtheROSclerotic Plaque by Serial CCTA (ACROSS) is designed as a prospective observational study which aim is to demonstrate the effect of statins on coronary atherosclerosis, assessed by quantitative analysis of CCTA.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: February 28, 2020

Interventions

  • Drug: Atorvastatin
    • Patients diagnosed with coronary artery disease by CCTA be enrolled. Among enrolled patients, patients who is indicated to statin treatment according to the current ACC/AHA guideline will be treated with atorvastatin.

Clinical Trial Outcome Measures

Primary Measures

  • Difference in percent change of total atheroma volume assessed by CCTA between statin-taking and statin-naïve group
    • Time Frame: 24 months
    • Patients indicated with statin therapy according to current guideline will receive atorvastatin.

Secondary Measures

  • Change of total atheroma volume at 24 months compared with baseline total atheroma volume
    • Time Frame: 24 months
    • total atheroma volume assessed by CCTA

Participating in This Clinical Trial

Inclusion Criteria

  • Patients who underwent clinically indicated CCTA (index CCTA) – Mild to moderate stenosis (25-69%) on CCTA – ≥1 clinical risk factors (Smoking, HTN, HDL<40, Premature FHx, M ≥45, F ≥55) for CAD Exclusion Criteria:

  • Acute coronary syndrome (unstable angina or MI) – Positive (not equivocal) stress test – Contraindications to statin

Gender Eligibility: All

Minimum Age: 19 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Yonsei University
  • Collaborator
    • Chong Kun Dang Pharmaceutical Corp.
  • Provider of Information About this Clinical Study
    • Principal Investigator: Hyuk-Jae Chang, Professor – Yonsei University
  • Overall Official(s)
    • Hyuk-Jae Chang, MD, PhD, Principal Investigator, Yonsei University
  • Overall Contact(s)
    • Hyuk-Jae Chang, MD, PhD, +82-2-2228-8454, hjchang@yuhs.ac

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