Biomarkers in Patients Undergoing Atrial Fibrillation Ablation

Overview

The investigators aim to find biomarkers to determine the success of pulmonary vein isolation for the treatment of atrial fibrillation.

Full Title of Study: “A Single-center Observational Study to Find Biomarkers for the Outcome of Catheter Ablation in Patients With Atrial Fibrillation”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: July 2018

Detailed Description

The investigators perform an observational study in patients undergoing pulmonary vein ablation to treat atrial fibrillation. Additionally, electrophysiological procedures not related to pulmonary vein isolation are also followed. The aim of the study is finding biomarkers that are able to predict short-term outcome of the procedure.The primary endpoint is defined as reoccurrences of atrial fibrillation within the first three months after pulmonary vein isolation.

Interventions

  • Procedure: Catheter Ablation

Arms, Groups and Cohorts

  • Atrial fibrillation ablation group
    • Patients undergoing catheter ablation for the treatment of atrial fibrillation.
  • Electrophysiological study group
    • Patients undergoing a diagnostic electrophysiological study without ablation.
  • Atrial flutter ablation group
    • Patients undergoing catheter ablation of right atrial flutter at the cavotricuspid isthmus.

Clinical Trial Outcome Measures

Primary Measures

  • Number of patients with short term reoccurrences of atrial fibrillation after ablation.
    • Time Frame: 3 months
    • Holter ECGs and ECGs after atrial fibrillation ablation

Secondary Measures

  • Change in heart rate after pulmonary vein isolation
    • Time Frame: 3 days.
    • Heart rates are recorded at admission and release from the hospital.

Participating in This Clinical Trial

Inclusion Criteria

  • patients with atrial fibrillation scheduled for pulmonary vein isolation with either radiofrequency of cryoballoon – patients scheduled for an electrophysiological study without ablation – patients with a catheter ablation at the cavotricuspid isthmus for the treatment of right atrial flutter Exclusion Criteria:

  • patients with concurrent pulmonary vein isolation and ablation of the cavotricuspid isthmus – Acute myocardial infarction, coronary artery bypass graft surgery or open heart surgery within less than 3 months prior to inclusion

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Universitätsklinikum Hamburg-Eppendorf
  • Provider of Information About this Clinical Study
    • Principal Investigator: Prof. Dr. Christian Meyer, Prof. Dr. Christian Meyer – Universitätsklinikum Hamburg-Eppendorf
  • Overall Official(s)
    • Christian Meyer, Prof. Dr., Principal Investigator, Germany Department of Cardiology – Electrophysiology, University Heart Centre

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