Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness
Overview
The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.
Full Title of Study: “Longitudinal Interaction Between APOA5 -1131T>C and Overweight”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: December 1, 2013
Interventions
- Genetic: rs662799 (APOA5 -1131T>C)
- Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism.
Arms, Groups and Cohorts
- Normal weight
- nondiabetic and nonobese individuals (18.5 kg/m2 ≤ BMI < 25 kg/m2, n=349)
- Overweight
- nondiabetic and nonobese individuals (25 kg/m2 ≤ BMI < 30 kg/m2, n=154)
Clinical Trial Outcome Measures
Primary Measures
- Brachial-ankle PWV (baPWV)
- Time Frame: at baseline
- cm/s
- Brachial-ankle PWV (baPWV)
- Time Frame: 3-year follow-up
- cm/s
Secondary Measures
- Triglyceride
- Time Frame: at baseline
- mg/dL
- Triglyceride
- Time Frame: 3-year follow-up
- mg/dL
Participating in This Clinical Trial
Inclusion Criteria
- Nondiabetic (fasting serum glucose concentration < 126 mg/dL) – Nonobese (BMI ≥ 25 kg/m2) Exclusion Criteria:
- Current and/or past history of cardiovascular disease – Diabetes mellitus (fasting glucose levels ≥126 mg/dL) – Abnormal liver or renal function – Thyroid or pituitary disease – Pregnancy or lactation – Regular use of any medication
Gender Eligibility: All
Minimum Age: 30 Years
Maximum Age: 65 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Yonsei University
- Provider of Information About this Clinical Study
- Principal Investigator: Jong Ho Lee, Professor – Yonsei University
- Overall Official(s)
- Jong Ho Lee, PhD, Principal Investigator, Dept. of Food and Nutrition, Colleage of Human Ecology, Yonsei University
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