Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness

Overview

The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.

Full Title of Study: “Longitudinal Interaction Between APOA5 -1131T>C and Overweight”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 1, 2013

Interventions

  • Genetic: rs662799 (APOA5 -1131T>C)
    • Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism.

Arms, Groups and Cohorts

  • Normal weight
    • nondiabetic and nonobese individuals (18.5 kg/m2 ≤ BMI < 25 kg/m2, n=349)
  • Overweight
    • nondiabetic and nonobese individuals (25 kg/m2 ≤ BMI < 30 kg/m2, n=154)

Clinical Trial Outcome Measures

Primary Measures

  • Brachial-ankle PWV (baPWV)
    • Time Frame: at baseline
    • cm/s
  • Brachial-ankle PWV (baPWV)
    • Time Frame: 3-year follow-up
    • cm/s

Secondary Measures

  • Triglyceride
    • Time Frame: at baseline
    • mg/dL
  • Triglyceride
    • Time Frame: 3-year follow-up
    • mg/dL

Participating in This Clinical Trial

Inclusion Criteria

  • Nondiabetic (fasting serum glucose concentration < 126 mg/dL) – Nonobese (BMI ≥ 25 kg/m2) Exclusion Criteria:

  • Current and/or past history of cardiovascular disease – Diabetes mellitus (fasting glucose levels ≥126 mg/dL) – Abnormal liver or renal function – Thyroid or pituitary disease – Pregnancy or lactation – Regular use of any medication

Gender Eligibility: All

Minimum Age: 30 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Yonsei University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jong Ho Lee, Professor – Yonsei University
  • Overall Official(s)
    • Jong Ho Lee, PhD, Principal Investigator, Dept. of Food and Nutrition, Colleage of Human Ecology, Yonsei University

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