Lipoprotein-associated Phospholipase A2 in Patients With Type 2 Diabetes

Overview

Lipoprotein-associated phospholipase A2 (LP-PLA2) is a good marker of cardiovascular risk and inflammation. This study aims at the characteristic and clinical significance of LP-PLA2 test in patients with type 2 diabetes(T2D).

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: August 31, 2016

Detailed Description

The investigators recorded clinical factors, serum levels of glucose, HbA1c, lipids and LP-PLA2 in patients with T2D who visited in the Department of Endocrinology at the Nanjing First Hospital from January 2015 to August 2016. The relationship between levels of LP-PLA2 and diabetic complications are analysed.

Clinical Trial Outcome Measures

Primary Measures

  • Lipoprotein-associated Phospholipase A2
    • Time Frame: Day one
    • the plasma lipoprotein-associated phospholipase A2 level of patients

Secondary Measures

  • HbA1c
    • Time Frame: Day one
    • the glycosylated hemoglobin level of patients
  • LDL-c
    • Time Frame: Day one
    • low density lipoprotein cholesterol
  • Diabetic Complication
    • Time Frame: Day one
    • the prevalence of atherosclerosis, diabetic Nephropathy, diabetic retinopathy and diabetic neuropathy
  • C Peptide
    • Time Frame: Day one
    • fast and 120min postprandial C peptide

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with T2D and the diagnostic criteria of T2D is according to the World Health Organization in 1999. Exclusion Criteria:

1. Patients use systemic steroidal anti-inflammatory drugs. 2. Patients are pregnant. 3. Patients with an acute infection.

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Investigator Details

  • Lead Sponsor
    • Nanjing First Hospital, Nanjing Medical University
  • Provider of Information About this Clinical Study
    • Sponsor

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