Platelet Function With Various Storage Techniques
Overview
Platelet function will be tested in individuals on antiplatelet medications to determine the optimal storage methodology.
Full Title of Study: “The Impact of Various Storage Techniques on Platelet Function”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Treatment
- Masking: Double (Investigator, Outcomes Assessor)
- Study Primary Completion Date: July 15, 2019
Detailed Description
Subjects will undergo administration of antiplatelet drugs and then will receive platelets stored in a variety of methods. Platelet function will be measured serially.
Interventions
- Biological: Infusion of Platelets
- Platelets will be stored using novel, FDA approved, technique. Subjects will receive infusion of platelets stored by novel technique, routine storage, and placebo (saline).
- Biological: Infusion of Platelets
- Platelets will be stored using the routine platelet storage method. Subjects will receive infusion of platelets stored by routine storage method.
- Biological: Placebo
- Subjects will receive infusion placebo (saline).
Arms, Groups and Cohorts
- Placebo Comparator: Control (Placebo)
- Subjects will receive infusion of placebo (saline).
- Active Comparator: Platelet storage routine
- Subjects will receive infusion of platelets stored by routine method.
- Experimental: Platelet storage experimental
- Subjects will receive infusion of platelets stored by a novel methodology.
Clinical Trial Outcome Measures
Primary Measures
- Change in platelet function
- Time Frame: 1 hour post-transfusion
- Frozen platelets will result in improvement in platelet function after transfusion.
Participating in This Clinical Trial
Inclusion Criteria
- Normal subjects Exclusion Criteria:
- Pre existing antiplatelet drugs
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 65 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Northwell Health
- Provider of Information About this Clinical Study
- Sponsor
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