Description of the Interdigitation Retinal Area by SD-OCT: An Exploratory Study

Overview

Improvement of retinal medical imaging opens new perspectives for exploring the retinal structures. Optical coherence spectral domain (SD-OCT), which has been widely used in the last ten years, is certainly the most advanced device. In the analysis of patients without retinal disease using SD-OCT, granulations in the interdigitation area were observed. These granulations have never been described with this device. They could correspond either to the degradation products of the external segments of the photoreceptors or to melanosomes. A descriptive study of these granulations at different examination times and in different lighting situations would allow us to obtain essential information for a better understanding of this area. Based on the results, larger studies could explore this area more finely in retinal pathologies involving dysfunctions of photoreceptors or of the pigmentary epithelium.

Full Title of Study: “Description of the Interdigitation Retinal Area by SD-OCT (Spectral Domain Optical Coherence Tomography): An Exploratory Study (ODIGIT)”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: January 10, 2018

Interventions

  • Device: Spectral Domain Optical Coherence Tomography
    • Five SD-OCTs will be performed with various conditions of enlightenment.

Arms, Groups and Cohorts

  • Other: Normal conditions of light exposure
    • Spectral Domain Optical Coherence Tomography (SD-OCT): Five SD-OCTs will be produced under the same lighting conditions (photopic). At baseline 20 minutes after baseline 25 minutes after baseline 45 minutes after baseline 60 minutes after baseline
  • Other: Light variations
    • Spectral Domain Optical Coherence Tomography (SD-OCT): Five SD-OCT will be performed: at baseline, in a room with photopic artificial lighting (400 lux) after a period of adaptation to the dark (20 minutes in the dark: 0 lux) after 5 min of retinal glare, obtained by means of a projection of light of 1000 lux on the fundus of eye 15 minutes after this period of retinal glare, in photopic artificial lighting 30 minutes after the period of retinal glare, in photopic artificial lighting

Clinical Trial Outcome Measures

Primary Measures

  • Variation of the number of hyperreflective granulations in the interdigitation area according to time and enlightenment
    • Time Frame: 1 hour after baseline

Participating in This Clinical Trial

Inclusion Criteria

  • Patient aged 18 years or older – Consent to participate Exclusion Criteria:

  • Retinal abnormalities

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Fondation Ophtalmologique Adolphe de Rothschild
  • Provider of Information About this Clinical Study
    • Sponsor

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