Comparing Human Albumin Versus Hydroxyethylstarch in Renal Transplant Recipients
Overview
In this study we try to review the possible effects when using modern hydroxyethylstarch solutions 6 % versus albumin 5% during living donor renal transplantation.
Full Title of Study: “Plasma Volume Expansion for Optimum Renal Transplant Surgery: Albumin Versus Starch”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Supportive Care
- Masking: Single (Participant)
- Study Primary Completion Date: February 1, 2019
Interventions
- Other: Albumin resuscitation
- Albumin 5% is used as the intra-operative colloid
- Other: Hydroxyethylstarch resuscitation
- Hydroxyethyl starch 6% is used as the intra-operative colloid
- Drug: Albumin 5%
- Infusion of Albumin 5% intra-operatively
- Drug: Hydroxyethylstarch 6%
- Infusion of Hydroxyethylstarch 6% intra-operatively
Arms, Groups and Cohorts
- Active Comparator: Albumin group
- Albumin resuscitation Albumin 5%
- Experimental: Hydroxyethylstarch group
- Hydroxyethylstarch resuscitation Hydroxyethylstarch 6%
Clinical Trial Outcome Measures
Primary Measures
- Occurrence of complications
- Time Frame: 7 days
- Increased creatinine and/or need for dialysis
Participating in This Clinical Trial
Inclusion Criteria
- end stage renal disease, for living donor renal transplantation Exclusion Criteria:
- severe cardiac or hepatic dysfunction, re-transplantation, coagulopathy
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 60 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Cairo University
- Provider of Information About this Clinical Study
- Principal Investigator: Ahmed Kareem, Principal Investigator – Cairo University
- Overall Official(s)
- Ahmed Kareem, Study Director, Kasr Al-Ainy Hospiral, Cairo University
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