Study to Develop a Breath Analyser to Detect Chronic Kidney Disease

Overview

Measure trimethylamine oxide in the breath.

Full Title of Study: “Pilot Study to Develop a Breath Analyser to Detect Chronic Kidney Disease”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: November 30, 2023

Detailed Description

Organic compounds such as trimethylamine oxide (TMAO) accumulate in the blood of patients with kidney disease, and volatile compounds such as TMAO can be detected in the breath. The investigators wish to develop a breath analyser to measure volatile compounds, such as TMAO in the breath in patients with kidney disease.

Interventions

  • Diagnostic Test: breath
    • measurement of volatile compounds, such as TMAO in exhaled breath and blood

Arms, Groups and Cohorts

  • patients on dialysis
    • patients with kidney disease treated by dialysis
  • patients with chronic kidney disease
    • patients with chronic kidney disease not treated by dialysis

Clinical Trial Outcome Measures

Primary Measures

  • measurement of breath TMAO
    • Time Frame: 3 years
    • measurement of breath TMAO by breath analyser

Participating in This Clinical Trial

Inclusion Criteria

  • patients with kidney disease under the care of Royal Free Hospital Exclusion Criteria:

  • patients unable to provide informed consent – patients unable to exhale into breath analyser

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 90 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University College, London
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • andrew davenport, md, Principal Investigator, UCL, London
  • Overall Contact(s)
    • andrew davenport, md, 442077940500, andrewdavenport@nhs.net

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