Metabolomic Study in Huntington’s Disease (METABO-HD)

Overview

The purpose of this project is to study Huntington's disease by metabolomic approach.

Full Title of Study: “Metabolomic Study in Huntington’s Disease”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Other
    • Masking: None (Open Label)
  • Study Primary Completion Date: September 2019

Interventions

  • Biological: blood sample
    • blood sample for metabolome analyse

Arms, Groups and Cohorts

  • Experimental: presymptomatic
  • Experimental: symptomatic
  • Other: controls

Clinical Trial Outcome Measures

Primary Measures

  • metabolite mass
    • Time Frame: at baseline
    • by chromatography and mass spectrometry

Participating in This Clinical Trial

Inclusion Criteria

For all groups:

  • age between 20 and 70 years – signature of the informed consent – covered by social security For presymptomatic group: – positive genetic test with CAG repeat length ≥ 37 in HTT gene – Unified Huntington Disease Rating Scale ≤ 5 For symptomatic group: – positive genetic test with CAG repeat length ≥ 37 in HTT gene – The Unified Huntington's Disease Rating Scale motor score ≥ 6 – The Total Functional Capacity score ≥ 11 Exclusion Criteria for all groups: – participation in another therapeutic trial (3 months exclusion period) – pregnancy and breastfeeding – persons deprived of their liberty by judicial or administrative decision

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University Hospital, Angers
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Christophe Verny, PU-PH, Principal Investigator, University Hospital, Angers
  • Overall Contact(s)
    • Christophe Verny, PU-PH, 0241355615, Chverny@chu-angers.fr

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