Idiopathic Pulmonary Fibrosis (IPF) and the 3 Minutes Sit-to-stand Test

Overview

This study is designed to evaluate the reproductibility and the performance of the 3 minutes sit-to-stand test in patients with idiopathic pulmonary fibrosis. To do this, the investigators are recruiting 40 patients with idiopathic pulmonary fibrosis in 2 centers (Grenoble university hospital and Lyon university hospital). Patients had to achieve an effort test on a cycle ergometer. 2 visits are planned in the hospital. During each visit, patients will perform a 3 minutes sit-to-stand test, a 1 minute sit-to-stand test and a 6 minutes walk test. During the second visit, patients will also perform a 3 minutes sit-to-stand test with measurement of oxygen uptake. The investigators will then analyse the results by comparing numbers of cycle, functional response and symptoms during the 3 minutes sit-to-stand test of the 2 visits. The investigators will also compare the functional response obtained during the 3 minutes sit-to-stand test, the 1 minute sit-to-stand test and the 6 minutes walk test. Finally, the investigators will compare the maximal values of oxygen uptake, respiration rate and expired volume obtained during the 3 minutes sit-to-stand test to the effort test on cycle ergometer.

Full Title of Study: “Assessment of the Reproducibility of the 3 Minutes Sit-to-stand Test in Patients With Idiopathic Pulmonary Fibrosis (IPF)”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: December 9, 2018

Interventions

  • Diagnostic Test: 3 minutes sit-to-stand test
    • 3 minutes sit-to-stand test, 1 minute sit-to-stand test, 6 minutes walk test will be performed 2 times for each patients 3 minutes sit-to-stand test with oxygen uptake measurement will be performed one time for each patient

Arms, Groups and Cohorts

  • Experimental: patient with idiopathic pulmonary fibrosis

Clinical Trial Outcome Measures

Primary Measures

  • Reproductibility of the 3 minutes sit-to-stand test in patient with idiopathic pulmonary fibrosis
    • Time Frame: 2 days
    • Evaluate the reproductibility for the number of rise and down during the 3 minutes sit-to-stand test of the 2 visits (the investigators will compare the number of rise and sit during the 3 minutes sit-to-stand test of the 2 visits to see if they are similar)

Secondary Measures

  • Functional response during the 3 minutes sit-to-stand test: Oxygen saturation
    • Time Frame: 2 days
    • Evaluate the reproductibility of functional response (oxygen saturation) during the 3 minutes sit-to-stand test
  • 3 minutes sit-to-stand test compared to the 6 minutes walk test: oxygen saturation
    • Time Frame: 2 days
    • compared oxygen saturation during the 3 minutes sit-to-stand test to the 6 minutes walk test
  • 1 minute sit-to-stand test compared to 3 minutes sit-to-stand: oxygen saturation
    • Time Frame: 2 days
    • Compared oxygen saturation during the 3 minutes sit-to-stand test with 1 minute sit-to-stand test
  • Functional response during the 3 minutes sit-to-stand test: Heart rate
    • Time Frame: 2 days
    • Evaluate the reproductibility of functional response (heart rate) during the 3 minutes sit-to-stand test
  • Functional response during the 3 minutes sit-to-stand test: symptoms
    • Time Frame: 2 days
    • Evaluate the reproductibility of functional response (symptoms) during the 3 minutes sit-to-stand test
  • 3 minutes sit-to-stand test compared to the 6 minutes walk test: heart rate
    • Time Frame: 2 days
    • Compared heart rate during the 3 minutes sit-to-stand test to the 6 minutes walk test
  • 3 minutes sit-to-stand test compared to the 6 minutes walk test: symptoms
    • Time Frame: 2 days
    • Compared symptoms during the 3 minutes sit-to-stand test to the 6 minutes walk test
  • 1 minute sit-to-stand test compared to 3 minutes sit-to-stand: heart rate
    • Time Frame: 2 days
    • Compared heart rate during the 3 minutes sit-to-stand test with 1 minute sit-to-stand test
  • 1 minute sit-to-stand test compared to 3 minutes sit-to-stand: symptoms
    • Time Frame: 2 days
    • Compared symptoms during the 3 minutes sit-to-stand test with 1 minute sit-to-stand test

Participating in This Clinical Trial

Inclusion Criteria

  • man or woman aged less than 85 years – patients with Idiopathic Pulmonary Fibrosis without any acute exacerbation during 4 months before the inclusion – Non-opposition to participation in research – Patient with 6 minutes walk test > 200 meters (with or without oxygen therapy) Exclusion Criteria:

  • Patient with reduced locomotor activity, or joint pain that compromises the performance of the tests – Patient with 6 minutes walk test < 200 meters – Patient with an other etiology of pulmonary fibrosis – Other significant pulmonary diseases – Patient with unstable cardiac disease – Patient who may be, according to the investigator's assessment, not cooperating or respecting the obligations inherent in participating to the study. – Opposition to participation in research

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 85 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University Hospital, Grenoble
  • Provider of Information About this Clinical Study
    • Sponsor

Citations Reporting on Results

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