Effect of Hyaluronidase on Intraocular Pressure

Overview

The aim of this study is to evaluate effect of retrobulbar local anaesthesia after addition of hyaluronidase on IOP during cataract surgery

Full Title of Study: “Effect of Hyaluronidase on Intraocular Pressure After Retrobulbar Anaesthesia During Cataract Surgery”

Study Type

• Study Type: Interventional
• Study Design
  • Allocation: N/A
  • Intervention Model: Single Group Assignment
  • Primary Purpose: Diagnostic
  • Masking: None (Open Label)
• Study Primary Completion Date: September 2018

Interventions

• Drug: Hyaluronidase
  • 4ml of retrobulbar LA with addition of 15IU/ml hyaluronidase to 2% lidocaine

Arms, Groups and Cohorts

• Experimental: Effect of hyaluronidase on IOP

Clinical Trial Outcome Measures

Primary Measures

• reduction in IOP
  • Time Frame: within 10minutes
  • reduction of complications of high IOP during surgery

Participating in This Clinical Trial

Inclusion Criteria

• 1-Patients above the age of 50 years. 2-Patients with age related cataract. 3-Normal IOP. Exclusion Criteria:

• 1History of trauma. 2-Patients with glaucoma. 3-Previous ocular surgery. 4-Patients with other ocular pathology. 5-Uncontrolled diabetes or hypertension. 6-hypersensitivity to lignocaine. 7-Uncooperative or epileptic patients.

Gender Eligibility: All

Minimum Age: 50 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

• Lead Sponsor
  • Assiut University
• Provider of Information About this Clinical Study
  • Principal Investigator: Eman Yassin Ahmed, Principal Investigator – Assiut University
• Overall Contact(s)
  • Eman Yassin, 00201004686028, emanyassin08@gmail.com