The Study of Bacteriology and Pathogen Drug Sensitivity of Chronic Dacryocystitis


An observational study was designed to research the bacteriology and pathogen drug sensitivity of chronic dacryocystitis in China and optimize antibiotic therapy.

Study Type

  • Study Type: Observational [Patient Registry]
  • Study Design
    • Time Perspective: Other
  • Study Primary Completion Date: April 17, 2018

Detailed Description

For patients diagnosed with chronic dacryocystitis´╝îwe will collect the secretions after lacrimal passage irrigation, note the characters of the secretions and send the secretions for bacteria culture, analysis and pathogen drug sensitivity.


  • Diagnostic Test: bacterial culture and analysis
    • Specimens were collected with soft-tipped applicators of sterile cotton swabs after syphilis of lacrimal passages.

Clinical Trial Outcome Measures

Primary Measures

  • Bacterial agents
    • Time Frame: 2 weeks
    • Specimens will be collected after irrigation of the lacrimal passage and be sent for bacterial culture and bacterial analysis.

Secondary Measures

  • Sensitivity test
    • Time Frame: 2 weeks
    • The drugs tested include Penicilin, Amikacin, Azithromycin, Cefoxitin, Levofloxacin´╝îOfloxacin, Cefuroxime and Tobramycin.
  • The colour of lacrimal sac secretion
    • Time Frame: 2 weeks
    • The colour of lacrimal sac secretion will be identified by the doctor during the irrigation of the lacrimal passage.
  • The character of lacrimal sac secretion
    • Time Frame: 2 weeks
    • The lacrimal sac secretion will be classified as mucus or pus.

Participating in This Clinical Trial

Inclusion Criteria

1. Diagnosed with chronic dacryocystitis

2. No involvement in other drug experiment in the past 1 week

Exclusion Criteria

1. Can not cooperate the specimen collection

2. With any other eye disease

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Sun Yat-sen University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Wang Zhichong, cornea department chief – Sun Yat-sen University
  • Overall Contact(s)
    • Zhang Xiulan, M.D., 02087335367,

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