The purpose of this study is to explore the facial characteristics associated with the increased risk of coronary artery diseases. The secondary purpose is to evaluate the diagnostic efficacy of appearance factors for coronary artery diseases.
- Study Type: Observational
- Study Design
- Time Perspective: Retrospective
- Study Primary Completion Date: October 31, 2018
Several age-related appearance factors were described associated with increased risk of coronary artery diseases (CAD). However, several limitations made these facial risk factors hard to be utilized in clinical practice, including 1) low prevalence in CAD patients, 2) lack of specific definition, 3) poor reproducibility in artificial recognition.
Thus, we designed a case-control study to explore new, common and well-defined facial characteristics associated with CAD and evaluate the diagnostic efficacy of appearence factors in CAD. We will recuit 1150 patients with at least one coronary lesion stenosis ≥50% according to coronary angiography or coronary computer tomography (CAD group) and 1150 patients without coronary lesion stenosis≥ 50% (No CAD group) judged by coronary angiography or coronary computer tomography. We will collect patients' baseline information and facial images. One hand, we will explore the facial factors associated with CAD by comparing the exposure rates of different facial factors in CAD group and No CAD group based on artificial intelligence technology. On the other hand, we will build a CAD risk model based on facial factors, and evaluate the diagnostic effect of the model.
- Other: Facial characteristics
- The exposures are facial characteristics which differ significantly in exposure rates between coronary artery disease (CAD) group and no CAD group.
Arms, Groups and Cohorts
- Coronary artery disease (CAD) group
- Patients enrolled with at least one coronary lesion stenosis ≥50% according to coronary computer tomography or coronary angiography will be assigned to CAD group.
- No CAD group
- Patients enrolled without coronary lesion stenosis ≥50% according to coronary computer tomography or coronary angiography will be assigned to CAD group.
Clinical Trial Outcome Measures
- The association between facial factors and increased risk of coronary artery diseases
- Time Frame: at the end of enrollment (6 months)
Participating in This Clinical Trial
- Undergoing coronary computer tomography or coronary angiography
- Written informed consent
- Prior percutaneous coronary intervention (PCI)
- Prior coronary artery bypass graft (CABG)
- Without blood biochemistry outcome
- With artificially facial alteration (i.e. cosmetic surgery, facial trauma or make-up)
- Other situations which make patients fail to be photographed
Gender Eligibility: All
Minimum Age: N/A
Maximum Age: N/A
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
- Lead Sponsor
- China National Center for Cardiovascular Diseases
- Provider of Information About this Clinical Study
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