Immediate Dentoalveolar Restoration Compared to Bio-oss


This randomised controlled trial compares the immediate dentoalveolar restoration and bovine demineralised bone in immediate implants placed in fresh sockets with buccal resorption. A total of 34 patients will be included and followed clinically and radiographically for 18 months. Patient centred outcomes will also be evaluated.

Full Title of Study: “Immediate Dentoalveolar Restoration Compared to Demineralized Bovine Bone in Immediate Implants Placed in Fresh Sockets With Buccal Bone Resorption: 18-months Randomized Controlled Trial”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Single (Investigator)
  • Study Primary Completion Date: January 2018


  • Procedure: Immediate dentoalveolar restoration
    • Block of bone removed from the tuber and placed in the buccal resorption of the socket together with an immediate implant
  • Procedure: Demineralized bovine bone
    • Block of demineralised bovine bone placed in the buccal resorption of the socket together with an immediate implant

Arms, Groups and Cohorts

  • Experimental: IDR
    • Immediate dentoalveolar restoration conducted with bone removed from the tuber
  • Active Comparator: Bio-oss
    • Bovine demineralized bone (Bio-oss Collagen) applied on the buccal resorption of the immediate implant

Clinical Trial Outcome Measures

Primary Measures

  • Buccal-palatal thickness
    • Time Frame: 18 months

Secondary Measures

  • Oral-health related quality of life
    • Time Frame: 18 months
    • The OHIP-14 will be applied and satisfaction will also be recorded

Participating in This Clinical Trial

Inclusion Criteria

  • Tooth extraction indicated for teeth in anterior area between second premolars Exclusion Criteria:
  • Diabetes and other systemic conditions that may affect osseointegration
  • Gender Eligibility: All

    Minimum Age: 18 Years

    Maximum Age: 65 Years

    Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

    Investigator Details

    • Lead Sponsor
      • Federal University of Rio Grande do Sul
    • Collaborator
      • University of the Republic, Uruguay
    • Provider of Information About this Clinical Study
      • Principal Investigator: Alex Nogueira Haas, Professor – Federal University of Rio Grande do Sul
    • Overall Contact(s)
      • Alex Haas, PhD, +555133085318,

    Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

    At, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.