Non-immune Related Hypothyroidism in Iodine Sufficient Area

Overview

Background: Autoimmune hypothyroidism has been regarded as the most common cause of primary hypothyroidism in iodine sufficient area and has relationship with excess iodine induced hypothyroidism. However, non-immune related hypothyroidism and its relationship with excess iodine have been rarely evaluated. Objective: Therefore, the investigators planned to calculate proportion of non-immune related hypothyroidism and relationship with iodine intake using nationwide data from Korea National Health and Nutrition Examination Survey (KNHANES) 2013-2015. Design: 1. Korea National Health and Nutrition Examination Survey VI (2013 to 2015) – The national data – which is the government designated statistics (Approval No. 117002 ) of South Korea based on the Article 17 of the National Health Promotion Act – were used. The survey was approved by the Institutional Review Board of the Korea Centers for Disease Control and Prevention, and provides only non-identified measures for academic research purposes. 2. The participants who were examined for thyroid stimulating hormone, free thyroxine, thyroid peroxidase antibody (TPO Ab), and urine iodine concentration (UIC) were included. 3. The proportion of immune related and non-immune related hypothyroidism was evaluated. Demographic variables and severity of hypothyroidism were compared between the two groups. To analyze iodine effect on hypothyroidism in TPO Ab positive or negative population, prevalence of hypothyroidism were assessed in each TPO Ab negative and positive population according to UIC subgroups. 4. This study protocol was approved by IRB of SMC (2017-05-149).

Study Type

  • Study Type: Observational [Patient Registry]
  • Study Design
    • Time Perspective: Other
  • Study Primary Completion Date: December 31, 2016

Interventions

  • Other: The investigators did not apply any intervention for the participants.
    • The investigators did not apply any intervention for the participants.

Clinical Trial Outcome Measures

Primary Measures

  • The weighted proportion of non-immune related hypothyroidism
    • Time Frame: 3 years
    • Hypothyroidism with TPO Ab negative

Participating in This Clinical Trial

Inclusion Criteria

  • examined for thyroid stimulating hormone, free thyroxine, thyroid peroxidase antibody (TPO Ab), and urine iodine concentration (UIC) Exclusion Criteria:

  • already have a thyroid disease(benign thyroid diseases or thyroid cancer).

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Investigator Details

  • Lead Sponsor
    • Samsung Medical Center
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jae Hoon Chung, M.D., Ph.D. – Samsung Medical Center

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