Patient-ventilator Asynchrony During Noninvasive Ventilation Assessed Using Diaphragm Ultrasonography
Overview
Fifteen healthy subjects under non-invasive ventilation will be have a recording of surface electromyogram, measurements of airway flows and pressures as well as a continuous ultrasound. The provocation of leaks on the Ventilation circuit and expiratory trigger modulation will generate a number of asynchronies between the subject and the respirator. These records will help to assess the agreement between the detection of asynchronies using electromyography of the respiratory muscles (technique of reference) and the diaphragmatic echography. We will also compare the respective performance of two techniques of diaphragmatic exploration (excursion and thickening of the diaphragm). A sensitivity of Ultrasound technique of at least 90% will be interpreted as a satisfactory index of concordance.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: N/A
- Intervention Model: Single Group Assignment
- Primary Purpose: Diagnostic
- Masking: None (Open Label)
- Study Primary Completion Date: July 30, 2017
Interventions
- Other: Creation and detection of patient-respirator asynchronies
- The provocation of leaks on the Ventilation circuit and expiratory trigger modulation will generate a number of asynchronies between the subject and the respirator
Arms, Groups and Cohorts
- Experimental: Healthy volunteers
Clinical Trial Outcome Measures
Primary Measures
- Asynchronies detection with diaphragm ultrasonography
- Time Frame: thirty minutes
- Evaluation of the agreement between asynchronous subject-ventilator detection using diaphragm ultrasonography and detecting the same events in using the electromyogram of the respiratory muscles (as a reference technique.
Participating in This Clinical Trial
Inclusion Criteria
- Healthy volunteer (male or female) – Free and Informed Consent Exclusion Criteria:
- Known pregnancy, parturient or nursing mother – Minor under 18 years of age – Major incapable – Non-affiliation to the social security scheme – Any history of respiratory pathology
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
- Provider of Information About this Clinical Study
- Sponsor
- Overall Contact(s)
- Guillaume Carteaux, Dr, + 33 1 49 81 23 94, guillaume.carteaux@gmail.com
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