Patient-ventilator Asynchrony During Noninvasive Ventilation Assessed Using Diaphragm Ultrasonography

Overview

Fifteen healthy subjects under non-invasive ventilation will be have a recording of surface electromyogram, measurements of airway flows and pressures as well as a continuous ultrasound. The provocation of leaks on the Ventilation circuit and expiratory trigger modulation will generate a number of asynchronies between the subject and the respirator. These records will help to assess the agreement between the detection of asynchronies using electromyography of the respiratory muscles (technique of reference) and the diaphragmatic echography. We will also compare the respective performance of two techniques of diaphragmatic exploration (excursion and thickening of the diaphragm). A sensitivity of Ultrasound technique of at least 90% will be interpreted as a satisfactory index of concordance.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: July 30, 2017

Interventions

  • Other: Creation and detection of patient-respirator asynchronies
    • The provocation of leaks on the Ventilation circuit and expiratory trigger modulation will generate a number of asynchronies between the subject and the respirator

Arms, Groups and Cohorts

  • Experimental: Healthy volunteers

Clinical Trial Outcome Measures

Primary Measures

  • Asynchronies detection with diaphragm ultrasonography
    • Time Frame: thirty minutes
    • Evaluation of the agreement between asynchronous subject-ventilator detection using diaphragm ultrasonography and detecting the same events in using the electromyogram of the respiratory muscles (as a reference technique.

Participating in This Clinical Trial

Inclusion Criteria

  • Healthy volunteer (male or female) – Free and Informed Consent Exclusion Criteria:

  • Known pregnancy, parturient or nursing mother – Minor under 18 years of age – Major incapable – Non-affiliation to the social security scheme – Any history of respiratory pathology

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Centre Hospitalier Saint Joseph Saint Luc de Lyon
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Contact(s)
    • Guillaume Carteaux, Dr, + 33 1 49 81 23 94, guillaume.carteaux@gmail.com

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