Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

Overview

This study will assess the short term effects of a single dose of liothyronine on the cardiovascular system and energy expenditure

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Other
    • Masking: Triple (Participant, Care Provider, Investigator)
  • Study Primary Completion Date: June 24, 2019

Interventions

  • Drug: Liothyronine
    • Single dose
  • Drug: Levothyroxine
    • Active comparator
  • Drug: Placebos
    • Placebo

Arms, Groups and Cohorts

  • Experimental: Liothyronine
    • Each participant will receive a single dose of lithyronine
  • Active Comparator: Levothyroxine
    • Each participant will receive a single dose of levothyroxine
  • Placebo Comparator: Placebo
    • Each participant will receive a single dose of placebo

Clinical Trial Outcome Measures

Primary Measures

  • Cardiac Output
    • Time Frame: five hours
    • Cardiac output measured by Echocaridogram, Difference in Stroke Volume Pre- and Post- Drug Administration

Secondary Measures

  • Energy Expenditure
    • Time Frame: five hours
    • Energy expenditure measured by Whole-Room Indirect Calorimeter, Difference in energy Expenditure Pre- and Post- Drug Administration Kcal

Participating in This Clinical Trial

Inclusion Criteria

  • BMI >20<30 kg/m2 – TSH >0.5<5.0 mcIU/mL – Negative TPO antibodies Exclusion Criteria:

  • Pregnancy – Use of prescription drugs – Diabetes mellitus – Coronary artery disease – Hypertension – Anemia – Renal insufficiency – Liver disease or ALT >2.5 x the upper laboratory reference limit

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Virginia Commonwealth University
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Francesco S Celi, MD, MHSc., Principal Investigator, Virginia Commonwealth University

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