Effects of Liothyronine on Energy Expenditure and Cardiovascular Function
Overview
This study will assess the short term effects of a single dose of liothyronine on the cardiovascular system and energy expenditure
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Other
- Masking: Triple (Participant, Care Provider, Investigator)
- Study Primary Completion Date: June 24, 2019
Interventions
- Drug: Liothyronine
- Single dose
- Drug: Levothyroxine
- Active comparator
- Drug: Placebos
- Placebo
Arms, Groups and Cohorts
- Experimental: Liothyronine
- Each participant will receive a single dose of lithyronine
- Active Comparator: Levothyroxine
- Each participant will receive a single dose of levothyroxine
- Placebo Comparator: Placebo
- Each participant will receive a single dose of placebo
Clinical Trial Outcome Measures
Primary Measures
- Cardiac Output
- Time Frame: five hours
- Cardiac output measured by Echocaridogram, Difference in Stroke Volume Pre- and Post- Drug Administration
Secondary Measures
- Energy Expenditure
- Time Frame: five hours
- Energy expenditure measured by Whole-Room Indirect Calorimeter, Difference in energy Expenditure Pre- and Post- Drug Administration Kcal
Participating in This Clinical Trial
Inclusion Criteria
- BMI >20<30 kg/m2 – TSH >0.5<5.0 mcIU/mL – Negative TPO antibodies Exclusion Criteria:
- Pregnancy – Use of prescription drugs – Diabetes mellitus – Coronary artery disease – Hypertension – Anemia – Renal insufficiency – Liver disease or ALT >2.5 x the upper laboratory reference limit
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 45 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Virginia Commonwealth University
- Provider of Information About this Clinical Study
- Sponsor
- Overall Official(s)
- Francesco S Celi, MD, MHSc., Principal Investigator, Virginia Commonwealth University
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