Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study

Overview

Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 < 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations. Its prevalence varies between 4 and 32%. Numerous treatments have been tried but the only efficient therapy to cure the syndrome is liver transplantation. Without transplantation it is associated with a higher mortality which is the reason why hepatopulmonary syndrome patients have a higher priority to transplantation. However it appears in some restricted studies that hepatopulmonary syndrome is associated with more postoperative complications (infections, vascular and biliary complications, prolonged length of mechanical ventilation…).

The investigators hypothesised that hepatopulmonary syndrome patients have more postoperative complications after liver transplantation than non hepatopulmonary syndrome patients matched on age, MELD (Model for End-Stage Liver Disease) score, comorbidities, perioperative transfusion and noradrenaline doses.

Full Title of Study: “Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study.”

Study Type

• Study Type: Observational
• Study Design
  • Time Perspective: Retrospective
• Study Primary Completion Date: March 31, 2017

Arms, Groups and Cohorts

• hepatic transplant patients with hepatopulmonary syndrome
• hepatic transplant patients without hepatopulmonary syndrome

Clinical Trial Outcome Measures

Primary Measures

• Postoperative complication rates in hepatic transplant patients with or without hepatopulmonary syndrome
  • Time Frame: 1 year post liver transplantation
  • Collection of medical (cardiac, pulmonary, renal, infectious, neurological) and Surgical (vascular, digestive) complications in hepatic transplant patients with or without hepatopulmonary syndrome

Secondary Measures

• Length of Mechanical Ventilation
  • Time Frame: 1 year post liver transplantation
• Length of ICU stay
  • Time Frame: 1 year post liver transplantation
• Length of Hospital Stay
  • Time Frame: 1 year post liver transplantation
• Delay of hepatopulmonary syndrome resolution
  • Time Frame: 1 year post liver transplantation

Participating in This Clinical Trial

Inclusion Criteria

• Liver transplanted patients

Exclusion Criteria

• Living donor transplantation
• Bipartition transplantation
• Non-heat-beating donor transplantation
• Minor
• Double or multiple organ transplantation
• Non cirrhotic patients
• Retransplantation

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

• Lead Sponsor
  • Hospices Civils de Lyon
• Provider of Information About this Clinical Study
  • Sponsor