Fluid ORiented Therapy for yoUNg Asa 1patients


In this retrospective analysis investigators will study the effects of using a minimally invasive hemodynamic monitoring (FloTrac-Edwards) on postoperative outcomes. Participants will compare a control group to a case group; in both groups ASA 1 patients suffering from advanced ovarian cancer underwent radical cytoreductive surgery. In case group hemodynamic was managed by using the FloTrac system; in the control group a standard hemodynamic monitoring was used.

Full Title of Study: “Effects of the Goal-directed Fluid Therapy on ASA 1 Patients Scheduled for Intensive Debulking Surgery”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: July 2015


  • Device: FloTrac
    • For patients belonging to case group a Pulse Contour Analysis was adopted for optimize fluid administration

Arms, Groups and Cohorts

  • No Intervention: control group
    • patients in which standard fluid administration was applied
  • Active Comparator: case group
    • patients in which fluids were administered according to FloTrac parameters

Clinical Trial Outcome Measures

Primary Measures

  • prevalence of complications
    • Time Frame: up to 30 days

Secondary Measures

  • days of hospitalization
    • Time Frame: up to 12 weeks

Participating in This Clinical Trial

Inclusion Criteria

  • ASA 1 Exclusion Criteria:

  • cardiac diseases – pulmonary diseases – renal diseases – metabolic disorders

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Fondazione Policlinico Universitario Agostino Gemelli IRCCS
  • Provider of Information About this Clinical Study
    • Principal Investigator: Dr.Andrea Russo, Medical Doctor – Fondazione Policlinico Universitario Agostino Gemelli IRCCS
  • Overall Official(s)
    • Andrea MD Russo, Principal Investigator, Department of Anesthesiology

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