Role of SWE-change After TIPS in the Prediction of Prognosis After TIPS
Overview
The aim of our prospective multicenter study was to investigate the prognostic value of the acute and long-term changes of liver stiffness in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS).
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: November 30, 2015
Detailed Description
We included 83 patients receiving TIPS for prevention of rebleeding, therapy-refractory ascites or both. Hemodynamic parameters were assessed before TIPS and after TIPS insertion. 16 patients from Freiburg underwent TE immediately before and after TIPS. In 67 patients from Bonn, SWE of liver and spleen, as well as clinical and biochemical parameters were assessed before TIPS, seven days and six weeks after TIPS.
Interventions
- Diagnostic Test: Stiffness measurement
- Transient Elastopgraphy (TE) or Shear-Wave-Elastography
Arms, Groups and Cohorts
- 1
- receiving TE before and 30 min after TIPS
- 2
- receiving SWE before and 7 days, 6 weeks and 3 months after TIPS
Clinical Trial Outcome Measures
Primary Measures
- Survival
- Time Frame: 3 months
Secondary Measures
- Acute-on-chronic Lvier failure
- Time Frame: 3 months
Participating in This Clinical Trial
Inclusion Criteria
- TIPS insertion and had reliable SWE or TE measurement Exclusion Criteria:
- contraindication for TIPS – no reliable SWE or TE measurement
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Jonel Trebicka
- Provider of Information About this Clinical Study
- Sponsor-Investigator: Jonel Trebicka, Prof. Dr. – University Hospital, Bonn
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