Role of SWE-change After TIPS in the Prediction of Prognosis After TIPS

Overview

The aim of our prospective multicenter study was to investigate the prognostic value of the acute and long-term changes of liver stiffness in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS).

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: November 30, 2015

Detailed Description

We included 83 patients receiving TIPS for prevention of rebleeding, therapy-refractory ascites or both. Hemodynamic parameters were assessed before TIPS and after TIPS insertion. 16 patients from Freiburg underwent TE immediately before and after TIPS. In 67 patients from Bonn, SWE of liver and spleen, as well as clinical and biochemical parameters were assessed before TIPS, seven days and six weeks after TIPS.

Interventions

  • Diagnostic Test: Stiffness measurement
    • Transient Elastopgraphy (TE) or Shear-Wave-Elastography

Arms, Groups and Cohorts

  • 1
    • receiving TE before and 30 min after TIPS
  • 2
    • receiving SWE before and 7 days, 6 weeks and 3 months after TIPS

Clinical Trial Outcome Measures

Primary Measures

  • Survival
    • Time Frame: 3 months

Secondary Measures

  • Acute-on-chronic Lvier failure
    • Time Frame: 3 months

Participating in This Clinical Trial

Inclusion Criteria

  • TIPS insertion and had reliable SWE or TE measurement Exclusion Criteria:

  • contraindication for TIPS – no reliable SWE or TE measurement

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Jonel Trebicka
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Jonel Trebicka, Prof. Dr. – University Hospital, Bonn

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